Now showing items 1-4 of 4

    • Adult hippocampal neurogenesis and pattern separation in DG: a role for feedback inhibition in modulating sparseness to govern population-based coding 

      McAvoy, Kathleen; Besnard, Antoine; Sahay, Amar (Frontiers Media S.A., 2015)
      The dentate gyrus (DG) of mammals harbors neural stem cells that generate new dentate granule cells (DGCs) throughout life. Behavioral studies using the contextual fear discrimination paradigm have found that selectively ...
    • Adult neurogenesis modifies excitability of the dentate gyrus 

      Ikrar, Taruna; Guo, Nannan; He, Kaiwen; Besnard, Antoine; Levinson, Sally; Hill, Alexis; Lee, Hey-Kyoung; Hen, Rene; Xu, Xiangmin; Sahay, Amar (Frontiers Media S.A., 2013)
      Adult-born dentate granule neurons contribute to memory encoding functions of the dentate gyrus (DG) such as pattern separation. However, local circuit-mechanisms by which adult-born neurons partake in this process are ...
    • Dedifferentiation of committed epithelial cells into stem cells in vivo 

      Tata, Purushothama Rao; Mou, Hongmei; Pardo-Saganta, Ana; Zhao, Rui; Prabhu, Mythili; Law, Brandon M.; Vinarsky, Vladimir; Cho, Josalyn L.; Breton, Sylvie; Sahay, Amar; Medoff, Benjamin D.; Rajagopal, Jayaraj (2014)
      Summary Cellular plasticity contributes to the regenerative capacity of plants, invertebrates, teleost fishes, and amphibians. In vertebrates, differentiated cells are known to revert into replicating progenitors, but these ...
    • In Vivo Imaging of Adult Human Hippocampal Neurogenesis: Progress, Pitfalls and Promise 

      Ho, N F; Hooker, Jacob M; Sahay, Amar; Holt, Daphne Jane; Roffman, Joshua Lawrence (Springer Nature, 2013)
      New neurons are produced within the hippocampus of the mammalian brain throughout life. Evidence from animal studies has suggested that the function of these adult-born neurons is linked to cognition and emotion. Until we ...