Browsing by Author "Rosen, Bruce"

Now showing items 1-20 of 22

    • Acupuncture mobilizes the brain's default mode and its anti-correlated network in healthy subjects 

      Hui, Kathleen K.S.; Marina, Ovidiu; Claunch, Joshua D.; Nixon, Erika E.; Fang, Jiliang; Liu, Jing; Li, Ming; Napadow, Vitaly J.; Vangel, Mark G.; Makris, Nikos; Chan, Suk Tak; Kwong, Kenneth Kin Man; Rosen, Bruce (Elsevier BV, 2009)
      Previous work has shown that acupuncture stimulation evokes deactivation of a limbic-paralimbic-neocortical network (LPNN) as well as activation of somatosensory brain regions. This study explores the activity and functional ...

    • Acupuncture on GB34 activates the precentral gyrus and prefrontal cortex in Parkinson’s disease 

      Yeo, Sujung; Choe, Il-Hwan; van den Noort, Maurits; Bosch, Peggy; Jahng, Geon-Ho; Rosen, Bruce; Kim, Sung-Hoon; Lim, Sabina (BioMed Central, 2014)
      Background: Acupuncture is increasingly used as an additional treatment for patients with Parkinson’s disease (PD). Methods: In this functional magnetic resonance imaging study, brain activation in response to acupuncture ...

    • Brain Genomics Superstruct Project initial data release with structural, functional, and behavioral measures 

      Holmes, Avram J.; Hollinshead, Marisa O.; O’Keefe, Timothy M.; Petrov, Victor I.; Fariello, Gabriele R.; Wald, Lawrence L.; Fischl, Bruce; Rosen, Bruce R.; Mair, Ross W.; Roffman, Joshua L.; Smoller, Jordan W.; Buckner, Randy L. (Nature Publishing Group, 2015)
      The goal of the Brain Genomics Superstruct Project (GSP) is to enable large-scale exploration of the links between brain function, behavior, and ultimately genetic variation. To provide the broader scientific community ...

    • Characterization of the "Deqi" Response in Acupuncture 

      Liu, Jing; Hui, Kathleen; Nixon, Erika; Vangel, Mark; Marina, Ovidiu; Napadow, Vitaly; Hodge, Steven; Rosen, Bruce; Makris, Nikos; Kennedy, David (Springer Science and Business Media LLC, 2007-10-31)
      Background: Acupuncture stimulation elicits deqi, a composite of unique sensations that is essential for clinical efficacy according to traditional Chinese medicine (TCM). There is lack of adequate experimental data to ...

    • Dopamine D1 signaling organizes network dynamics underlying working memory 

      Roffman, Joshua L.; Tanner, Alexandra S.; Eryilmaz, Hamdi; Rodriguez-Thompson, Anais; Silverstein, Noah J.; Ho, New Fei; Nitenson, Adam Z.; Chonde, Daniel B.; Greve, Douglas N.; Abi-Dargham, Anissa; Buckner, Randy L.; Manoach, Dara S.; Rosen, Bruce R.; Hooker, Jacob M.; Catana, Ciprian (American Association for the Advancement of Science, 2016)
      Local prefrontal dopamine signaling supports working memory by tuning pyramidal neurons to task-relevant stimuli. Enabled by simultaneous positron emission tomography–magnetic resonance imaging (PET-MRI), we determined ...

    • Effects of ferumoxytol on quantitative PET measurements in simultaneous PET/MR whole-body imaging: a pilot study in a baboon model 

      Borra, Ronald JH; Cho, Hoon-Sung; Bowen, Spencer L; Attenberger, Ulrike; Arabasz, Grae; Catana, Ciprian; Josephson, Lee; Rosen, Bruce R; Guimaraes, Alexander R; Hooker, Jacob M (Springer International Publishing, 2015)
      Background: Simultaneous PET/MR imaging depends on MR-derived attenuation maps (mu-maps) for accurate attenuation correction of PET data. Currently, these maps are derived from gradient-echo-based MR sequences, which are ...

    • Evoked itch perception is associated with changes in functional brain connectivity 

      Desbordes, Gaëlle; Li, Ang; Loggia, Marco L.; Kim, Jieun; Schalock, Peter C.; Lerner, Ethan; Tran, Thanh N.; Ring, Johannes; Rosen, Bruce R.; Kaptchuk, Ted J.; Pfab, Florian; Napadow, Vitaly (Elsevier, 2014)
      Chronic itch, a highly debilitating condition, has received relatively little attention in the neuroimaging literature. Recent studies suggest that brain regions supporting itch in chronic itch patients encompass sensorimotor ...

    • Functional MRI of Rehabilitation in Chronic Stroke Patients Using Novel MR-Compatible Hand Robots 

      Mintzopoulos, Dionyssios; Khanicheh, Azadeh; Konstas, Angelos A.; Astrakas, Loukas G; Singhal, Aneesh B.; Moskowitz, Michael Arthur; Rosen, Bruce; Tzika, A. Aria (Bentham Open, 2008)
      We monitored brain activation after chronic stroke by combining functional magnetic resonance imaging (fMRI) with a novel MR-compatible, hand-induced, robotic device (MR_CHIROD). We evaluated 60 fMRI datasets on a 3 T MR ...

    • Glial activation colocalizes with structural abnormalities in amyotrophic lateral sclerosis 

      Alshikho, Mohamad J.; Zürcher, Nicole R.; Loggia, Marco L.; Cernasov, Paul; Chonde, Daniel B.; Izquierdo Garcia, David; Yasek, Julia E.; Akeju, Oluwaseun; Catana, Ciprian; Rosen, Bruce R.; Cudkowicz, Merit E.; Hooker, Jacob M.; Atassi, Nazem (Lippincott Williams & Wilkins, 2016)
      Objective: In this cross-sectional study, we aimed to evaluate brain structural abnormalities in relation to glial activation in the same cohort of participants. Methods: Ten individuals with amyotrophic lateral sclerosis ...

    • The imagined itch: brain circuitry supporting nocebo-induced itch in atopic dermatitis patients 

      Napadow, Vitaly J.; Li, Ang; Loggia, Marco Luciano; Kim, Jieun; Mawla, Ishtiaq; Desbordes, Gaelle; Schalock, P. C.; Lerner, Ethan Arthur; Tran, Thanh-Nga Trinh; Ring, Johannes; Rosen, Bruce; Kaptchuk, Ted Jack; Pfab, Florian (Wiley-Blackwell, 2015)
      Background Psychological factors are known to significantly modulate itch in patients suffering from chronic itch. Itch is also highly susceptible to both placebo and nocebo (negative placebo) effects. Brain activity ...

    • Improved PET Data Quantification in Simultaneous PET/MR Neuroimaging 

      Chonde, Daniel B. (2015-05-16)
      Recently, systems that integrate positron emission tomography and magnetic resonance imaging (PET/MR) have become available for clinical use. This new technology, which combines the high spatial resolution and superior ...

    • Improved Tumor Oxygenation and Survival in Glioblastoma Patients Who Show Increased Blood Perfusion After Cediranib and Chemoradiation 

      Batchelor, Tracy; Gerstner, Elizabeth; Emblem, Kyrre E.; Duda, Dan; Kalpathy-Cramer, Jayashree; Snuderl, Matija; Ancukiewicz, Marek; Polaskova, Pavlina; Pinho, Marco C.; Jennings, Dominique; Plotkin, Scott; Chi, Andrew S.; Eichler, April; Dietrich, Jorg; Hochberg, Fred H.; Lu-Emerson, Christine; Iafrate, Anthony; Ivy, S. Percy; Rosen, Bruce; Loeffler, Jay; Wen, Patrick; Sorenson, A. Greg; Jain, Rakesh (National Academy of Sciences, 2013-11-19)
      Antiangiogenic therapy has shown clear activity and improved survival benefit for certain tumor types. However, an incomplete understanding of the mechanisms of action of antiangiogenic agents has hindered optimization and ...

    • Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: Assessed with [11C]-PBR28 

      Zürcher, Nicole R.; Loggia, Marco L.; Lawson, Robert; Chonde, Daniel B.; Izquierdo-Garcia, David; Yasek, Julia E.; Akeju, Oluwaseun; Catana, Ciprian; Rosen, Bruce R.; Cudkowicz, Merit E.; Hooker, Jacob M.; Atassi, Nazem (Elsevier, 2015)
      Evidence from human post mortem, in vivo and animal model studies implicates the neuroimmune system and activated microglia in the pathology of amyotrophic lateral sclerosis. The study aim was to further evaluate in vivo ...

    • Neural Encoding of Acupuncture Needling Sensations: Evidence from a fMRI Study 

      Wang, Xiaoling; Chan, Suk-Tak; Fang, Jiliang; Nixon, Erika E.; Liu, Jing; Kwong, Kenneth K.; Rosen, Bruce R.; Hui, Kathleen K. S. (Hindawi Publishing Corporation, 2013)
      Deqi response, a psychophysical response characterized by a spectrum of different needling sensations, is essential for Chinese acupuncture clinical efficacy. Previous neuroimaging research works have investigated the ...

    • Neuroprotective changes in degeneration-related gene expression in the substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism: Microarray analysis 

      Yeo, Sujung; An, Keon Sang; Hong, Yeon-Mi; Choi, Yeong-Gon; Rosen, Bruce; Kim, Sung-Hoon; Lim, Sabina (Sociedade Brasileira de Genética, 2015)
      Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the death of dopamine-generating cells in the substantia nigra (SN). Acupuncture stimulation results in an enhanced survival of dopaminergic neurons ...

    • Neurovascular coupling to D2/D3 dopamine receptor occupancy using simultaneous PET/functional MRI 

      Sander, C. Y.; Hooker, Jacob M; Catana, Ciprian; Normandin, Marc D; Alpert, Nathaniel Moritz; Knudsen, G. M.; Vanduffel, Wim J.M.; Rosen, Bruce; Mandeville, Joseph B. (Proceedings of the National Academy of Sciences, 2013)
      This study employed simultaneous neuroimaging with positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) to demonstrate the relationship between changes in receptor occupancy measured by PET ...

    • OA08.04. Brain circuitry subserving acupuncture relief of itch in atopic dermatitis: an fMRI study 

      Napadow, Vitaly J.; Li, A.; Loggia, Marco Luciano; Kim, J.; Schalock, Peter C.; Lerner, Ethan Arthur; Rosen, Bruce; Kaptchuk, Ted Jack; Pfab, F (BioMed Central, 2012)

    • Quantitative Oxygen Extraction Fraction from 7-Tesla MRI Phase: Reproducibility and Application in Multiple Sclerosis 

      Fan, Audrey P.; Govindarajan, Sindhuja T.; Kinkel, R. Phillip; Madigan, Nancy K.; Nielsen, A. Scott; Benner, Thomas; Tinelli, Emanuele; Rosen, Bruce; Adalsteinsson, Elfar; Mainero, Caterina (SAGE Publications, 2014-10-29)
      Quantitative oxygen extraction fraction (OEF) in cortical veins was studied in patients with multiple sclerosis (MS) and healthy subjects via magnetic resonance imaging (MRI) phase images at 7 Tesla (7 T). Flow-compensated, ...

    • A Receptor-Based Model for Dopamine-Induced fMRI Signal 

      Mandeville, Joseph B.; Sander, Christin Y.M.; Jenkins, Bruce Gorton; Hooker, Jacob M; Catana, Ciprian; Vanduffel, Wim J.M.; Alpert, Nathaniel Moritz; Rosen, Bruce; Normandin, Marc D (Elsevier BV, 2013)
      This report describes a multi-receptor physiological model of the fMRI temporal response and signal magnitude evoked by drugs that elevate synaptic dopamine in basal ganglia. The model is formulated as a summation of ...

    • Repeatability of Cerebral Perfusion Using Dynamic Susceptibility Contrast MRI in Glioblastoma Patients12 

      Jafari-Khouzani, Kourosh; Emblem, Kyrre E.; Kalpathy-Cramer, Jayashree; Bjørnerud, Atle; Vangel, Mark G.; Gerstner, Elizabeth R.; Schmainda, Kathleen M.; Paynabar, Kamran; Wu, Ona; Wen, Patrick Y.; Batchelor, Tracy; Rosen, Bruce; Stufflebeam, Steven M. (Neoplasia Press, 2015)
      OBJECTIVES This study evaluates the repeatability of brain perfusion using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) with a variety of post-processing methods. METHODS Thirty-two patients with ...