Browsing by Author "Liu, Xiaowen"

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    • Efficacy of Metreleptin in Obese Patients With Type 2 Diabetes: Cellular and Molecular Pathways Underlying Leptin Tolerance 

      Matarese, Giuseppe; Brennan, Aoife M.; Chamberland, John P.; Fiorenza, Christina G.; Mylvaganam, Geetha H.; Abanni, Luisa; Carbone, Fortunata; De Paoli, Alex M.; Moon, Hyun-Seuk; Liu, Xiaowen; Williams, Catherine J.; Schneider, Benjamin Edward; Mantzoros, Christos (American Diabetes Association, 2011)
      Objective: Metreleptin has been efficacious in improving metabolic control in patients with lipodystrophy, but its efficacy has not been tested in obese patients with type 2 diabetes. Research Design and Methods: We studied ...

    • Lack of mature lymphocytes results in obese but metabolically healthy mice when fed a high-fat diet 

      Liu, Xiaowen; Huh, Joo Young; Gong, Huizhi; Chamberland, John; Hamnvik, Ole-Petter Riksfjord; Mantzoros, Christos (Springer Science and Business Media LLC, 2015-05-21)
      Background/Objectives: Obesity is characterized by chronic inflammation and immune dysregulation, as well as insulin resistance, but the link between obesity and adaptive immunity remains to be fully studied. Methods: To ...