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Nelson, Shawn

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Nelson

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Shawn

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Nelson, Shawn
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    Efficient Routes to a Diverse Array of Amino Alcohol-Derived Chiral Fragments
    (American Chemical Society, 2016) Haftchenary, Sina; Nelson, Shawn; Furst, Laura; Dandapani, Sivaraman; Ferrara, Steven J.; Bošković, Žarko V.; Figueroa Lazú, Samuel; Guerrero, Adrian M.; Serrano, Juan C.; Crews, DeMarcus K.; Brackeen, Cristina; Mowat, Jeffrey; Brumby, Thomas; Bauser, Marcus; Schreiber, Stuart; Phillips, Andrew J.
    Efficient syntheses of chiral fragments derived from chiral amino alcohols are described. Several unique scaffolds were readily accessed in 1–5 synthetic steps leading to 45 chiral fragments, including oxazolidinones, morpholinones, lactams, and sultams. These fragments have molecular weights ranging from 100 to 255 Da and are soluble in water (0.085 to >15 mM).