Publication: Efficient Routes to a Diverse Array of Amino Alcohol-Derived Chiral Fragments
Open/View Files
Date
2016
Published Version
Journal Title
Journal ISSN
Volume Title
Publisher
American Chemical
Society
The Harvard community has made this article openly available. Please share how this access benefits you.
Citation
Haftchenary, S., S. D. Nelson, L. Furst, S. Dandapani, S. J. Ferrara, Ž. V. Bošković, S. Figueroa Lazú, et al. 2016. “Efficient Routes to a Diverse Array of Amino Alcohol-Derived Chiral Fragments.” ACS Combinatorial Science 18 (9): 569-574. doi:10.1021/acscombsci.6b00050. http://dx.doi.org/10.1021/acscombsci.6b00050.
Research Data
Abstract
Efficient syntheses of chiral fragments derived from chiral amino alcohols are described. Several unique scaffolds were readily accessed in 1–5 synthetic steps leading to 45 chiral fragments, including oxazolidinones, morpholinones, lactams, and sultams. These fragments have molecular weights ranging from 100 to 255 Da and are soluble in water (0.085 to >15 mM).
Description
Other Available Sources
Keywords
amino alcohols, fragment-based lead discovery, chiral fragments, drug discovery
Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material (LAA), as set forth at Terms of Service