(Public Library of Science, 2012) Qin, Yu; Schneider, Tobias; Brenner, Michael
Sequencing by Hybridization (SBH) reconstructs an n-long target DNA sequence from its biochemically determined \(l\)-long subsequences. In the standard approach, the length of a uniformly random sequence that can be unambiguously reconstructed is limited to \(n=O(2^{l})\) due to repetitive subsequences causing reconstruction degeneracies. We present a modified sequencing method that overcomes this limitation without the need for different types of biochemical assays and is robust to error.
