(American Chemical Society, 2011) Birrell, James Andrew; Desrosiers, Jean-Nicolas; Jacobsen, Eric
A highly-enantioselective acylation of silyl ketene acetals with acyl fluorides has been developed to generate useful (\alpha), (\alpha)-disubstituted butyrolactone products. This reaction is promoted by a new thiourea catalyst and 4-pyrrolidinopyridine and represents the first example of enantioselective thiourea anion-binding catalysis with fluoride.
