Publication: Enantioselective Acylation of Silyl Ketene Acetals through Fluoride Anion-Binding Catalysis
Loading...
Open/View Files
Date
2011
Published Version
Journal Title
Journal ISSN
Volume Title
Publisher
American Chemical Society
The Harvard community has made this article openly available. Please share how this access benefits you.
Citation
Birrell, James A., Jean-Nicolas Desrosiers, and Eric N. Jacobsen. 2011. Enantioselective acylation of silyl ketene acetals through fluoride anion-binding catalysis. Journal of the American Chemical Society 133(35): 13872 -13875.
Abstract
A highly-enantioselective acylation of silyl ketene acetals with acyl fluorides has been developed to generate useful (\alpha), (\alpha)-disubstituted butyrolactone products. This reaction is promoted by a new thiourea catalyst and 4-pyrrolidinopyridine and represents the first example of enantioselective thiourea anion-binding catalysis with fluoride.
Description
Other Available Sources
Research Data
Keywords
Terms of Use
This article is made available under the terms and conditions applicable to Open Access Policy Articles (OAP), as set forth at Terms of Service