Person: Velupillai, Palanivel
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Velupillai, Palanivel
Production of a Natural Antibody to the Mouse Polyoma Virus Is a Multigenic Trait
MA/MyJ mice express a natural antibody to the highly oncogenic polyoma virus. C57BR/cdJ mice lack this antibody but mount an adaptive T-cell response to the virus. Analysis of F2 progeny of a cross between these strains reveals a pattern of inheritance of expression of the natural antibody involving two genes in an epistatic relationship.