Publication: Production of a Natural Antibody to the Mouse Polyoma Virus Is a Multigenic Trait
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Date
2012
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Genetics Society of America
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Andrews, Erik, Palanivel Velupillai, Chang Kyoo Sung, David R. Beier, and Thomas Benjamin. 2012. Production of a natural antibody to the mouse polyoma virus is a multigenic trait. Genes, Genomes, Genetics 2(3): 353-355.
Abstract
MA/MyJ mice express a natural antibody to the highly oncogenic polyoma virus. C57BR/cdJ mice lack this antibody but mount an adaptive T-cell response to the virus. Analysis of F2 progeny of a cross between these strains reveals a pattern of inheritance of expression of the natural antibody involving two genes in an epistatic relationship.
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Keywords
natural antibody, polyoma virus, multigenic inheritance, epistasis
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