(American Chemical Society (ACS), 2013) Sladojevich, Filippo; Arlow, Sophie I.; Tang, Pingping; Ritter, Tobias
An operationally simple protocol for the selective deoxyfluorination of structurally complex alcohols is presented. Several fluorinated derivatives of natural products and pharmaceuticals have been prepared to showcase the potential of the method for late-stage diversification and its functional group compatibility. A series of simple guidelines for predicting the selectivity in substrates with multiple alcohols is given.
(American Chemical Society (ACS), 2013) Mazzotti, Anthony Renato; Campbell, Michael Glenn; Tang, Pingping; Murphy, Jennifer; Ritter, Tobias
A practical, palladium-catalyzed synthesis of aryl fluorides from arylboronic acid derivatives is presented. The reaction is operationally simple and amenable to multigram-scale synthesis. Evaluation of the reaction mechanism suggests a single-electron-transfer pathway, involving a Pd(III) intermediate that has been isolated and characterized.
