(2013-10-08) Mardinly, Alan Robert; Greenberg, Michael Eldon; Chen, Chinfei; Hensch, Takao; Fishell, Gordon
Neuronal activity and subsequent calcium influx activates a signaling cascade that causes transcription factors in the nucleus to rapidly induce an early-response program of gene expression. This early-response program is composed of transcriptional regulators that in turn induce transcription of late-response genes, which are enriched for regulators of synaptic development and plasticity that act locally at the synapse.
