Publication: Regulation of Synapse Development by Activity Dependent Transcription in Inhibitory Neurons
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2013-10-08
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Mardinly, Alan Robert. 2013. Regulation of Synapse Development by Activity Dependent Transcription in Inhibitory Neurons. Doctoral dissertation, Harvard University.
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Abstract
Neuronal activity and subsequent calcium influx activates a signaling cascade that causes transcription factors in the nucleus to rapidly induce an early-response program of gene expression. This early-response program is composed of transcriptional regulators that in turn induce transcription of late-response genes, which are enriched for regulators of synaptic development and plasticity that act locally at the synapse.
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Neurosciences, Activity, Inhibition, Npas4, somatostatin, synapse development
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