Person:
Li, Qian

Profile Picture

Email Address

AA Acceptance Date

Birth Date

Research Projects

Organizational Units

Job Title

Last Name

Li

First Name

Qian

Name

Li, Qian

Filters

20101

Settings

Author's Publications: search.filters.isAuthorOfPublication.656896d0-adc3-430a-ad5b-9c5fe2378dd3

Search Results

Now showing 1 - 1 of 1
  • Thumbnail Image
    Publication
    Loss of Insulin Signaling in Vascular Endothelial Cells Accelerates Atherosclerosis in Apolipoprotein E Null Mice
    (Elsevier BV, 2010) Rask-Madsen, Christian; Li, Qian; Freund, Bryn; Feather, Danielle; Abramov, Roman; Wu, I-Hsien; Chen, Kai; Yamamoto-Hiraoka, Junko; Goldenbogen, Jan; Sotiropoulos, Konstantinos B.; Clermont, Allen; Geraldes, Pedro; Dall, Claudia; Wagers, Amy; Huang, Paul; Rekhter, Mark; Scalia, Rosario; Kahn, C.; King, George
    To determine whether insulin action on endothelial cells promotes or protects against atherosclerosis, we generated apolipoprotein E null mice in which the insulin receptor gene was intact or conditionally deleted in vascular endothelial cells. Insulin sensitivity, glucose tolerance, plasma lipids, and blood pressure were not different between the two groups, but atherosclerotic lesion size was more than 2-fold higher in mice lacking endothelial insulin signaling. Endothelium-dependent vasodilation was impaired and endothelial cell VCAM-1 expression was increased in these animals. Adhesion of mononuclear cells to endothelium in vivo was increased 4-fold compared with controls but reduced to below control values by a VCAM-1-blocking antibody. These results provide definitive evidence that loss of insulin signaling in endothelium, in the absence of competing systemic risk factors, accelerates atherosclerosis. Therefore, improving insulin sensitivity in the endothelium of patients with insulin resistance or type 2 diabetes may prevent cardiovascular complications.