(2014) Gidon, Alexandre; Al-Bataineh, Mohammad M.; Jean-Alphonse, Frederic G.; Stevenson, Hilary; Watanabe, Tomoyuki; Louet, Claire; Khatri, Ashok; Calero, Guillermo; Pastor-Soler, Núria M.; Gardella, Thomas; Vilardaga, Jean-Pierre
The PTH receptor is one of the first GPCR found to sustain cAMP signaling after internalization of the ligand–receptor complex in endosomes. This unexpected model is adding a new dimension on how we think about GPCR signaling, but its mechanism is incompletely understood. We report here that endosomal acidification mediated by the PKA action on the v-ATPase provides a negative feedback mechanism by which endosomal receptor signaling is turned-off.
