Publication: Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase
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2014
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Gidon, A., M. M. Al-Bataineh, F. G. Jean-Alphonse, H. Stevenson, T. Watanabe, C. Louet, A. Khatri, et al. 2014. “Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase.” Nature chemical biology 10 (9): 707-709. doi:10.1038/nchembio.1589. http://dx.doi.org/10.1038/nchembio.1589.
Abstract
The PTH receptor is one of the first GPCR found to sustain cAMP signaling after internalization of the ligand–receptor complex in endosomes. This unexpected model is adding a new dimension on how we think about GPCR signaling, but its mechanism is incompletely understood. We report here that endosomal acidification mediated by the PKA action on the v-ATPase provides a negative feedback mechanism by which endosomal receptor signaling is turned-off.
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