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Jiang, Nan

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Jiang

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Nan

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Jiang, Nan
Author's Publications: search.filters.isAuthorOfPublication.a665b2e9-ecf7-43b5-81b8-d3892087ced0

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    A bilayered nanoshell for durable protection of single yeast cells against multiple, simultaneous hostile stimuli† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc01130c
    (Royal Society of Chemistry, 2018) Jiang, Nan; Ying, Guo-Liang; Yetisen, Ali K.; Montelongo, Yunuen; Shen, Ling; Xiao, Yu-Xuan; Busscher, Henk J.; Yang, Xiao-Yu; Su, Bao-Lian
    Single cell surface engineering provides the most efficient, non-genetic strategy to enhance cell stability. However, it remains a huge challenge to improve cell stability in complex artificial environments. Here, a soft biohybrid interfacial layer is fabricated on individual living-cell surfaces by their exposure to a suspension of gold nanoparticles and l-cysteine to form a protecting functional layer to which porous silica layers were bound yielding pores with a diameter of 3.9 nm. The living cells within the bilayered nanoshells maintained high viability (96 ± 2%) as demonstrated by agar plating, even after five cycles of simultaneous exposure to high temperature (40 °C), lyticase and UV light. Moreover, yeast cells encapsulated in bilayered nanoshells were more recyclable than native cells due to nutrient storage in the shell.
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    Painful Terminal Neuroma Prevention by Capping PRGD/PDLLA Conduit in Rat Sciatic Nerves
    (John Wiley and Sons Inc., 2018) Yi, Jiling; Jiang, Nan; Li, Binbin; Yan, Qiongjiao; Qiu, Tong; Swaminatha Iyer, Killugudi; Yin, Yixia; Dai, Honglian; Yetisen, Ali K.; Li, Shipu
    Abstract Neuroma formation after amputation as a long‐term deficiency leads to spontaneous neuropathic pain that reduces quality of life of patients. To prevent neuroma formation, capping techniques are implemented as effective treatments. However, an ideal, biocompatible material covering the nerves is an unmet clinical need. In this study, biocompatible characteristics presented by the poly(D,L‐lactic acid)/arginylglycylaspartic acid (RGD peptide) modification of poly{(lactic acid)‐co‐ [(glycolic acid)‐alt‐(L‐lysine)]} (PRGD/PDLLA) are evaluated as a nerve conduit. After being capped on the rat sciatic nerve stump in vivo, rodent behaviors and tissue structures are compared via autotomy scoring and histological analyses. The PRGD/PDLLA capped group gains lower autotomy score and improves the recovery, where inflammatory infiltrations and excessive collagen deposition are defeated. Transmission electron microscopy images of the regeneration of myelin sheath in both groups show that abnormal myelination is only present in the uncapped rats. Changes in related genes (MPZ, MBP, MAG, and Krox20) are monitored quantitative real‐time polymerase chain reaction (qRT‐PCR) for mechanism investigation. The PRGD/PDLLA capping conduits not only act as physical barriers to inhibit the invasion of inflammatory infiltration in the scar tissue but also provide a suitable microenvironment for promoting nerve repairing and avoiding neuroma formation during nerve recovery.
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    Neuroma Prevention: Painful Terminal Neuroma Prevention by Capping PRGD/PDLLA Conduit in Rat Sciatic Nerves (Adv. Sci. 6/2018)
    (John Wiley and Sons Inc., 2018) Yi, Jiling; Jiang, Nan; Li, Binbin; Yan, Qiongjiao; Qiu, Tong; Swaminatha Iyer, Killugudi; Yin, Yixia; Dai, Honglian; Yetisen, Ali K.; Li, Shipu
    Traumatic neuroma formation results in persistent post‐operative pain after amputation, which reduces quality of life in patients. In article number https://doi.org/10.1002/advs.201700876, Yixia Yin, Honglian Dai, and co‐workers report a method to prevent traumatic neuroma formation after surgery by using a synthetic polymeric capping conduit that can act as a physical barrier to inhibit the invasion of inflammatory infiltration and promote nerve repair.
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    Glucose‐Sensitive Hydrogel Optical Fibers Functionalized with Phenylboronic Acid
    (John Wiley and Sons Inc., 2017) Yetisen, Ali K.; Jiang, Nan; Fallahi, Afsoon; Montelongo, Yunuen; Ruiz‐Esparza, Guillermo U.; Tamayol, Ali; Zhang, Yu; Mahmood, Iram; Yang, Su‐A; Kim, Ki Su; Butt, Haider; Khademhosseini, Ali; Yun, Seok‐Hyun
    Hydrogel optical fibers are utilized for continuous glucose sensing in real time. The hydrogel fibers consist of poly(acrylamide‐co‐poly(ethylene glycol) diacrylate) cores functionalized with phenylboronic acid. The complexation of the phenylboronic acid and cis‐diol groups of glucose enables reversible changes of the hydrogel fiber diameter. The analyses of light propagation loss allow for quantitative glucose measurements within the physiological range.