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Chen, Haiqi

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Chen

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Haiqi

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Chen, Haiqi
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    Efficient, Continuous Mutagenesis in Human Cells Using a Pseudo-Random DNA Editor
    (Springer Science and Business Media LLC, 2019-12-16) Chen, Haiqi; Liu, Sophia; Padula, Samuel; Lesman, Daniel; Griswold, Kettner; Lin, Allen; Zhao, Tongtong; Marshall, Jamie; Chen, Fei
    Here, we describe TRACE, a method that enables continuous, targeted mutagenesis in human cells using a cytidine deaminase fused to T7 RNA polymerase. TRACE induces high rates of mutagenesis over multiple cell generations in genes under the control of a T7 promoter integrated in the genome. Using TRACE in a MEK1 inhibitor resistance screen, we identified functionally correlated mutations.