Person:
Husain, Zaheed

Profile Picture

Email Address

AA Acceptance Date

Birth Date

Research Projects

Organizational Units

Job Title

Last Name

Husain

First Name

Zaheed

Name

Husain, Zaheed

Filters

2007 - 200912010 - 20131

Settings

Author's Publications: search.filters.isAuthorOfPublication.b824a312-404e-48b2-8433-362df55ff155

Search Results

Now showing 1 - 2 of 2
  • Thumbnail Image
    Publication
    Tumor-derived lactate and myeloid-derived suppressor cells: Linking metabolism to cancer immunology
    (Landes Bioscience, 2013) Husain, Zaheed; Seth, Pankaj; Sukhatme, Vikas
    Many malignant cells produce increased amounts of lactate, which promotes the development of myeloid-derived suppressor cells (MDSCs). MDSCs, lactate, and a low pH in the tumor microenvironment inhibit the function of natural killer (NK) cells and T lymphocytes, hence allowing for disease progression. Ketogenic diets can deplete tumor-bearing animals from MDSCs and regulatory T cells, thereby improving their immunological profile.
  • Thumbnail Image
    Publication
    Genetic Fixity in the Human Major Histocompatibility Complex and Block Size Diversity in the Class I Region Including HLA-E
    (BioMed Central, 2007) Romero, Viviana; Romero, Tatiana; Clavijo, Olga P; Fici, Dolores A; Alford, Dennis R; Awdeh, Zuheir L; Zuñiga, Joaquin; El-Dahdah, Lama; Larsen, Charles; Duke-Cohan, Jonathan; Fox, Edward Alvin; Husain, Zaheed; Almeciga, Ingrid; Alper, Chester; Yunis, Edmond
    Background: The definition of human MHC class I haplotypes through association of HLA-A, HLA-Cw and HLA-B has been used to analyze ethnicity, population migrations and disease association. Results: Here, we present HLA-E allele haplotype association and population linkage disequilibrium (LD) analysis within the ~1.3 Mb bounded by HLA-B/Cw and HLA-A to increase the resolution of identified class I haplotypes. Through local breakdown of LD, we inferred ancestral recombination points both upstream and downstream of HLA-E contributing to alternative block structures within previously identified haplotypes. Through single nucleotide polymorphism (SNP) analysis of the MHC region, we also confirmed the essential genetic fixity, previously inferred by MHC allele analysis, of three conserved extended haplotypes (CEHs), and we demonstrated that commercially-available SNP analysis can be used in the MHC to help define CEHs and CEH fragments. Conclusion: We conclude that to generate high-resolution maps for relating MHC haplotypes to disease susceptibility, both SNP and MHC allele analysis must be conducted as complementary techniques.