Publication: Tumor-derived lactate and myeloid-derived suppressor cells: Linking metabolism to cancer immunology
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Date
2013
Published Version
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Publisher
Landes Bioscience
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Citation
Husain, Zaheed, Pankaj Seth, and Vikas P Sukhatme. 2013. “Tumor-derived lactate and myeloid-derived suppressor cells: Linking metabolism to cancer immunology.” Oncoimmunology 2 (11): e26383. doi:10.4161/onci.26383. http://dx.doi.org/10.4161/onci.26383.
Research Data
Abstract
Many malignant cells produce increased amounts of lactate, which promotes the development of myeloid-derived suppressor cells (MDSCs). MDSCs, lactate, and a low pH in the tumor microenvironment inhibit the function of natural killer (NK) cells and T lymphocytes, hence allowing for disease progression. Ketogenic diets can deplete tumor-bearing animals from MDSCs and regulatory T cells, thereby improving their immunological profile.
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Keywords
glycolysis, ketogenic diet, lactate, MDSCs, NK cells
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