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Lin, Allen

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Lin, Allen
Author's Publications: search.filters.isAuthorOfPublication.bb722d89-85de-475c-8863-d4907fba8452

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    Efficient, Continuous Mutagenesis in Human Cells Using a Pseudo-Random DNA Editor
    (Springer Science and Business Media LLC, 2019-12-16) Chen, Haiqi; Liu, Sophia; Padula, Samuel; Lesman, Daniel; Griswold, Kettner; Lin, Allen; Zhao, Tongtong; Marshall, Jamie; Chen, Fei
    Here, we describe TRACE, a method that enables continuous, targeted mutagenesis in human cells using a cytidine deaminase fused to T7 RNA polymerase. TRACE induces high rates of mutagenesis over multiple cell generations in genes under the control of a T7 promoter integrated in the genome. Using TRACE in a MEK1 inhibitor resistance screen, we identified functionally correlated mutations.
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    Publication
    Impact and Cost-effectiveness of Selective Human Papillomavirus Vaccination of Men Who Have Sex With Men
    (Oxford University Press, 2016) Lin, Allen; Ong, Koh J.; Hobbelen, Peter; King, Eleanor; Mesher, David; Edmunds, W. John; Sonnenberg, Pam; Gilson, Richard; Bains, Irenjeet; Choi, Yoon H.; Tanton, Clare; Soldan, Kate; Jit, Mark
    Abstract Background. Men who have sex with men (MSM) have a high lifetime risk of anogenital warts and cancers related to infection with human papillomavirus (HPV). They also benefit less from herd protection than heterosexual males in settings with female-only HPV vaccination. Methods. We evaluated the potential health impact and cost-effectiveness of offering vaccination to MSM who visit genitourinary medicine (GUM) clinics. We used a mathematical model of HPV 6/11/16/18 sexual transmission within an MSM population in England, parameterized with sexual behaviour, GUM attendance, HPV prevalence, HIV prevalence, warts, and cancer incidence data. Interventions considered were offering HPV vaccination to either HIV-positive MSM or MSM regardless of HIV status, for age bands 16–25, 16–30, 16–35, and 16–40 years. Results. Substantial declines in anogenital warts and male HPV-related cancer incidence are projected to occur following an offer of vaccination to MSM. MSM not attending GUM clinics will partially benefit from herd protection. Offering vaccination to HIV-positive MSM up to age 40 is likely to be cost-effective if vaccine procurement and administration costs are below £96.50 a dose. At £48 a dose, offering vaccination to all MSM up to age 40 is likely to be cost-effective. Conclusions. Quadrivalent HPV vaccination of MSM via GUM clinics is likely to be an effective and cost-effective way of reducing the burden of HPV-related disease in MSM.