(2013-10-15) Shao, Diane; Hahn, William C.; Weinberg, Robert; Janne, Pasi; Bass, Adam; Sabatini, David; Haigis, Kevin; Park, Peter
Oncogenes drive cancer by hijacking normal cellular functions involved in proliferation and survival. Suppression of the driving oncogene is highly effective for promoting tumor regression, a phenomenon termed "oncogenic addiction." By using unbiased genetic tools to functionally probe oncogenic addiction, we can identify cancer dependencies and characterize aspects of oncogenic signaling.
