Publication: DNA Self-Assembly of Targeted Near-Infrared-Responsive Gold Nanoparticles for Cancer Thermo-Chemotherapy
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Date
2012
Published Version
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Publisher
WILEY-VCH Verlag
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Citation
Xiao, Zeyu, Changwei Ji, Jinjun Shi, Eric M Pridgen, Jillian Frieder, Jun Wu, and Omid C Farokhzad. 2012. DNA self-assembly of targeted near-infrared-responsive gold nanoparticles for cancer thermo-chemotherapy. Angewandte Chemie International Edition 51(47): 11853-11857.
Research Data
Abstract
Targeted Cancer Therapy: Inspired by the ability of DNA hybridization, a targeted near-infrared (NIR) light-responsive delivery system has been developed through simple DNA self-assembly (PEG=polyethylene glycol). This DNA-based platform shows the ability of releasing therapeutics upon near-infrared irradiation, and remarkable targeted thermo- and chemotherapeutic efficacy in vitro and in vivo.
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Keywords
cancer, DNA, drug delivery, nanorods, near-infrared light
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