Publication: Gene Model Annotations for Drosophila melanogaster: The Rule-Benders
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Date
2015
Published Version
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Genetics Society of America
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Citation
Crosby, M. A., L. S. Gramates, G. dos Santos, B. B. Matthews, S. E. St. Pierre, P. Zhou, A. J. Schroeder, et al. 2015. “Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.” G3: Genes|Genomes|Genetics 5 (8): 1737-1749. doi:10.1534/g3.115.018937. http://dx.doi.org/10.1534/g3.115.018937.
Research Data
Abstract
In the context of the FlyBase annotated gene models in Drosophila melanogaster, we describe the many exceptional cases we have curated from the literature or identified in the course of FlyBase analysis. These range from atypical but common examples such as dicistronic and polycistronic transcripts, noncanonical splices, trans-spliced transcripts, noncanonical translation starts, and stop-codon readthroughs, to single exceptional cases such as ribosomal frameshifting and HAC1-type intron processing. In FlyBase, exceptional genes and transcripts are flagged with Sequence Ontology terms and/or standardized comments. Because some of the rule-benders create problems for handlers of high-throughput data, we discuss plans for flagging these cases in bulk data downloads.
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Keywords
bicistronic, stop-codon suppression, multiphasic exon, shared promoter, non-AUG translation start
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