Publication: A nanocrystal-based ratiometric pH sensor for natural pH ranges
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Date
2012
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Royal Society of Chemistry (RSC)
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Somers, Rebecca C., Ryan M. Lanning, Preston T. Snee, Andrew B. Greytak, Rakesh K. Jain, Moungi G. Bawendi, and Daniel G. Nocera. 2012. “A Nanocrystal-Based Ratiometric pH Sensor for Natural pH Ranges.” Chemical Science 3 (10): 2980. doi:10.1039/c2sc20212c.
Abstract
A ratiometric fluorescent pH sensor based on CdSe/CdZnS nanocrystal quantum dots (NCs) has been designed for biological pH ranges. The construct is formed from the conjugation of a pH dye (SNARF) to NCs coated with a poly(amido amine) (PAMAM) dendrimer. The sensor exhibits a well–resolved ratio response at pH values between 6 and 8 under linear or two–photon excitation, and in the presence of a 4% bovine serum albumin (BSA) solution.
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