Publication: Conformational Control of Energy Transfer: A Mechanism for Biocompatible Nanocrystal-Based Sensors
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Date
2012
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Wiley-Blackwell
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Citation
Kay, Euan R., Jungmin Lee, Daniel G. Nocera, and Moungi G. Bawendi. 2012. “Conformational Control of Energy Transfer: A Mechanism for Biocompatible Nanocrystal-Based Sensors.” Angewandte Chemie International Edition 52 (4) (December 6): 1165–1169. doi:10.1002/anie.201207181.
Research Data
Abstract
Fold-up fluorophore: A new paradigm for designing self-referencing fluorescent nanosensors is demonstrated by interfacing a pH-triggered molecular conformational switch with quantum dots. Analytedependent, large-amplitude conformational motion controls the distance between the nanocrystal energy donor and an organic FRET acceptor. The result is a fluorescence signal capable of reporting pH values from individual endosomes in living cells.
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Keywords
biosensors, fluorescent probes, quantum dots, molecular devices, molecular machines
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