Publication: Untargeted metabolomics for profiling oncogene-specific metabolic signatures of prostate cancer
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Date
2015
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Taylor & Francis
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Citation
Priolo, Carmen, and Massimo Loda. 2015. “Untargeted metabolomics for profiling oncogene-specific metabolic signatures of prostate cancer.” Molecular & Cellular Oncology 2 (4): e1001197. doi:10.1080/23723556.2014.1001197. http://dx.doi.org/10.1080/23723556.2014.1001197.
Abstract
Oncogene-associated metabolic signatures in prostate cancer, identified by an integrative analysis of cultured cells and murine and human tumors, suggest that AKT activation results in a glycolytic phenotype whereas MYC induces aberrant lipid metabolism. Heterogeneity in human tumors makes this simplistic interpretation obtained from experimental models more challenging. Metabolic reprogramming as a function of distinct molecular aberrations has major diagnostic and therapeutic implications.
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Keywords
AKT signaling, cancer metabolism, mass spectrometry, MYC, prostate cancer
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