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COVID-19 Versus Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and ATP

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Abraham, Edward, Guido Guidotti, Eliezer Rapaport, David Bower, Jack Brown, et al. 2020. "COVID-19 Versus Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and ATP." Pre-print.

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We previously published an article in Science discussing the role of ATP in cystic fibrosis (CF). (1) In this manuscript, we update the findings published in that article and add new evidence that the elevated levels of ATP in CF patients may have a protective benefit CF patients infected by SARS-CoV-2 and suffereing from COVID-19. By extension, we suggest a therapeutic regimen that may benefit COVID-19 in the general populaton.

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