Recent Submissions

  • Immune genes are hotspots of shared positive selection across birds and mammals 

    Shultz, Allison; Sackton, Timothy (eLife Sciences Publications, Ltd, 2019-01-08)
    Consistent patterns of positive selection in functionally similar genes can suggest a common selective pressure across a group of species. We use alignments of orthologous protein-coding genes from 39 species of birds to ...
  • Structural Basis of TRPV4 N Terminus Interaction with Syndapin/PACSIN1-3 and PIP2 

    Goretzki, Benedikt; Glogowski, Nina A.; Diehl, Erika; Duchardt-Ferner, Elke; Hacker, Carolin; Gaudet, Rachelle; Hellmich, Ute A. (Elsevier BV, 2018-12)
    Transient receptor potential (TRP) channels are polymodally regulated ion channels. TRPV4 (vanilloid 4) is sensitized by PIP2 and desensitized by Syndapin3/PACSIN3, which bind to the structurally uncharacterized TRPV4 N ...
  • Batrachotoxin acts as a stent to hold open homotetrameric prokaryotic voltage-gated sodium channels 

    Finol-Urdaneta, Rocio K.; McArthur, Jeffrey R.; Goldschen-Ohm, Marcel P.; Gaudet, Rachelle; Tikhonov, Denis B.; Zhorov, Boris S.; French, Robert J.; McArthur (Rockefeller University Press, 2018-12-26)
    Batrachotoxin (BTX), an alkaloid from skin secretions of dendrobatid frogs, causes paralysis and death by facilitating activation and inhibiting deactivation of eukaryotic voltage-gated sodium (Nav) channels, which underlie ...

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