Recent Submissions

  • Exposure sources, amounts and time course of gluten ingestion and excretion in patients with coeliac disease on a gluten‐free diet 

    Silvester, Jocelyn; Comino, Isabel; Rigaux, Lisa N.; Segura, Veronica; Green, Kathy H.; Cebolla, Angel; Weiten, Dayna; Dominguez, Remedios; Leffler, Daniel; Leon, Francisco; Bernstein, Charles N.; Graff, Lesley A.; Kelly, Ciaran; Sousa, Carolina; Duerksen, Donald R. (Wiley, 2020-11)
    Background A major deficit in understanding and improving treatment in coeliac disease (CD) is the lack of empiric data on real world gluten exposure. Aims To estimate gluten exposure on a gluten‐free diet (GFD) using ...
  • Intratumoral T cell response detected after personal neoantigen vaccine in a phase Ib glioblastoma trial 

    Keskin, Derin B.; Anandappa, Annabelle J.; Sun, Jing; Tirosh, Itay; Mathewson, Nathan; Li, Shuqiang; Oliveira, Giacomo; Giobbie-Hurder, Anita; Felt, Kristen; Gjini, Evisa; Shukla, Sachet A.; Hu, Zhuting; Li, Letitia; Le, Phuong M.; Allesøe, Rosa L.; Richman, Alyssa R.; Kowalczyk, Monika S.; Abdelrahman, Sara; Geduldig, Jack E.; Charbonneau, Sarah; Pelton, Kristine; Iorgulescu, Julian; Elagina, Liudmila; Zhang, Wandi; Olive, Oriol; McCluskey, Christine; Olsen, Lars R.; Stevens, Jonathan; Lane, William; Salazar, Andres M.; Daley, Heather; Wen, Patrick Y.; Chiocca, E. Antonio; Harden, Maegan; Lennon, Niall J.; Gabriel, Stacey; Getz, Gad; Lander, Eric S.; Regev, Aviv; Ritz, Jerome; Neuberg, Donna; Rodig, Scott J.; Ligon, Keith L.; Suvà, Mario L.; Wucherpfennig, Kai; Hacohen, Nir; Fritsch, Edward F.; Livak, Kenneth J.; Ott, Patrick A.; Wu, Catherine; Reardon, David A.; Keskin, Derin; Sulva, Mario
    Neoantigens, derived from tumor-specific protein-coding mutations, are exempt from central tolerance, can generate robust immune responses, and can function as bona fide tumor rejection antigens. Here, we demonstrate that ...
  • Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models 

    Keklikoglou, Donna; Cianciaruso, Chiara; Guc, Esra; Squadrito, Mario Leonardo; Spring, Laura M.; Tazzyman, Simon; Lambein, Lore; Poissonnier, Amanda; Ferraro, Gino B.; Baer, Caroline; Cassara, Antonino; Guichard, Alan; Iruela-Arispe, M. Luisa; Lewis, Claire E.; Coussens, Lisa M.; Bardia, Aditya; Jain, Rakesh K.; Pollard, Jeffrey W.; De Palma, Michele (Springer Science and Business Media LLC, 2018-12-31)
    Cytotoxic chemotherapy is an effective treatment for invasive breast cancer. However, experimental studies in mice also suggest pro-metastatic effects of chemotherapy. Primary tumours release extracellular vesicles (EVs), ...

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