Browsing by Author "Fischl, Bruce"

Now showing items 1-19 of 19

    • An algorithm for optimal fusion of atlases with different labeling protocols 

      Iglesias, Juan Eugenio; Sabuncu, Mert Rory; Aganj, Iman; Bhatt, Priyanka; Casillas, Christen; Salat, David H.; Boxer, Adam; Fischl, Bruce R.; Van Leemput, Koen (Elsevier BV, 2015)
      In this paper we present a novel label fusion algorithm suited for scenarios in which different manual delineation protocols with potentially disparate structures have been used to annotate the training scans (hereafter ...

    • as-PSOCT: Volumetric microscopic imaging of human brain architecture and connectivity 

      Wang, Hui; Magnain, Caroline; Wang, Ruopeng; Dubb, Jay; Varjabedian, Ani; Tirrell, Lee; Stevens, Allison; Augustinack, Jean; Konukoglu, Ender; Aganj, Iman; Frosch, Matthew; Schmahmann, Jeremy; Fischl, Bruce; Boas, David (Elsevier BV, 2018-01)
      Polarization sensitive optical coherence tomography (PSOCT) with serial sectioning has enabled the investigation of 3D structures in mouse and human brain tissue samples. By using intrinsic optical properties of back-scattering ...

    • Automated MRI Measures Identify Individuals with Mild Cognitive Impairment and Alzheimer's Disease 

      Desikan, Rahul S.; Cabral, Howard J.; Hess, Christopher P.; Dillon, William P.; Glastonbury, Christine M.; Weiner, Michael W.; Schmansky, Nicholas J.; Salat, David H.; Greve, Douglas N.; Buckner, Randy Lee; Fischl, Bruce R.; Alzheimer’s Disease Neuroimaging Initiative (Oxford University Press, 2009)
      Mild cognitive impairment can represent a transitional state between normal ageing and Alzheimer's disease. Non-invasive diagnostic methods are needed to identify mild cognitive impairment individuals for early therapeutic ...

    • Avoiding Symmetry-Breaking Spatial Non-Uniformity in Deformable Image Registration via a Quasi-Volume-Preserving Constraint 

      Aganj, Iman; Reuter, Martin; Sabuncu, Mert R.; Fischl, Bruce (Elsevier BV, 2015-02-01)
      The choice of a reference image typically influences the results of deformable image registration, thereby making it asymmetric. This is a consequence of a spatially non-uniform weighting in the cost function integral that ...

    • Brain Genomics Superstruct Project initial data release with structural, functional, and behavioral measures 

      Holmes, Avram J.; Hollinshead, Marisa O.; O’Keefe, Timothy M.; Petrov, Victor I.; Fariello, Gabriele R.; Wald, Lawrence L.; Fischl, Bruce; Rosen, Bruce R.; Mair, Ross W.; Roffman, Joshua L.; Smoller, Jordan W.; Buckner, Randy L. (Nature Publishing Group, 2015)
      The goal of the Brain Genomics Superstruct Project (GSP) is to enable large-scale exploration of the links between brain function, behavior, and ultimately genetic variation. To provide the broader scientific community ...

    • Comprehensive cellular‐resolution atlas of the adult human brain 

      Ding, Song‐Lin; Royall, Joshua J.; Sunkin, Susan M.; Ng, Lydia; Facer, Benjamin A.C.; Lesnar, Phil; Guillozet‐Bongaarts, Angie; McMurray, Bergen; Szafer, Aaron; Dolbeare, Tim A.; Stevens, Allison; Tirrell, Lee; Benner, Thomas; Caldejon, Shiella; Dalley, Rachel A.; Dee, Nick; Lau, Christopher; Nyhus, Julie; Reding, Melissa; Riley, Zackery L.; Sandman, David; Shen, Elaine; van der Kouwe, Andre; Varjabedian, Ani; Write, Michelle; Zollei, Lilla; Dang, Chinh; Knowles, James A.; Koch, Christof; Phillips, John W.; Sestan, Nenad; Wohnoutka, Paul; Zielke, H. Ronald; Hohmann, John G.; Jones, Allan R.; Bernard, Amy; Hawrylycz, Michael J.; Hof, Patrick R.; Fischl, Bruce; Lein, Ed S. (John Wiley and Sons Inc., 2016)
      ABSTRACT Detailed anatomical understanding of the human brain is essential for unraveling its functional architecture, yet current reference atlases have major limitations such as lack of whole‐brain coverage, relatively ...

    • Cortical Folding Patterns and Predicting Cytoarchitecture 

      Fischl, Bruce R.; Rajendran, Niranjini; Busa, Evelina; Augustinack, Jean C.; Hinds, Oliver; Yeo, Boon Thye Thomas; Mohlberg, Hartmut; Amunts, Katrin; Zilles, Karl (Oxford University Press, 2007)
      The human cerebral cortex is made up of a mosaic of structural areas, frequently referred to as Brodmann areas (BAs). Despite the widespread use of cortical folding patterns to perform ad hoc estimations of the locations ...

    • The Cortical Signature of Alzheimer's Disease: Regionally Specific Cortical Thinning Relates to Symptom Severity in Very Mild to Mild AD Dementia and is Detectable in Asymptomatic Amyloid-Positive Individuals 

      Dickerson, Bradford Clark; Bakkour, Akram; Salat, David H.; Feczko, Eric; Pacheco, Jenni; Greve, Douglas N.; Grodstein, Francine; Wright, Christopher Ian; Blacker, Deborah Lynne; Rosas, Herminia Diana; Sperling, Reisa Anne; Atri, Alireza; Growdon, John Herbert; Hyman, Bradley Theodore; Morris, John C.; Fischl, Bruce R.; Buckner, Randy Lee (Oxford University Press, 2009)
      Alzheimer's disease (AD) is associated with neurodegeneration in vulnerable limbic and heteromodal regions of the cerebral cortex, detectable in vivo using magnetic resonance imaging. It is not clear whether abnormalities ...

    • Differential Effects of Aging and Alzheimer's Disease on Medial Temporal Lobe Cortical Thickness and Surface Area 

      Dickerson, Bradford Clark; Feczko, Eric; Augustinack, Jean C.; Pacheco, Jenni; Morris, John C.; Fischl, Bruce; Buckner, Randy Lee (Elsevier, 2009)
      The volume of parcellated conical regions is a composite measure related to both thickness and surface area. It is not clear whether volumetric decreases in medial temporal lobe (MTL) cortical regions in aging and Alzheimer's ...

    • Evaluating the validity of volume-based and surface-based brain image registration for developmental cognitive neuroscience studies in children 4 to 11 years of age 

      Ghosh, Satrajit S; Kakunoori, Sita; Augustinack, Jean C.; Nieto-Castanon, Alfonso; Kovelman, Ioulia; Gaab, Nadine; Christodoulou, Joanna A; Triantafyllou, Christina; Gabrieli, John D.E.; Fischl, Bruce R. (Elsevier BV, 2010)
      Understanding the neurophysiology of human cognitive development relies on methods that enable accurate comparison of structural and functional neuroimaging data across brains from people of different ages. A fundamental ...

    • Gray matter volume reduction in rostral middle frontal gyrus in patients with chronic schizophrenia 

      Kikinis, Zora; Fallon, J.H.; Niznikiewicz, Margaret A.; Nestor, Paul Gerard; Davidson, C.; Bobrow, L.; Pelavin, P.E.; Fischl, Bruce R.; Yendiki, Anastasia; McCarley, Robert William; Kikinis, Ron; Kubicki, Marek R.; Shenton, Martha Elizabeth (Elsevier BV, 2010)
      The dorsolateral prefrontal cortex (DLPFC) is a brain region that has figured prominently in studies of schizophrenia and working memory, yet the exact neuroanatomical localization of this brain region remains to be defined. ...

    • Mid-Space-Independent Deformable Image Registration 

      Aganj, Iman; Iglesias, Juan Eugenio; Reuter, Martin; Sabuncu, Mert Rory; Fischl, Bruce (Elsevier BV, 2017-05-15)
      Aligning images in a mid-space is a common approach to ensuring that deformable image registration is symmetric – that it does not depend on the arbitrary ordering of the input images. The results are, however, generally ...

    • Multimodal Image Registration Through Simultaneous Segmentation 

      Aganj, Iman; Fischl, Bruce (IEEE, 2017-11)
      Multimodal image registration facilitates the combination of complementary information from images acquired with different modalities. Most existing methods require computation of the joint histogram of the images, while ...

    • Progression from selective to general involvement of hippocampal subfields in schizophrenia 

      Ho, New Fei; Iglesias, Juan Eugenio; Sum, Min Yi; Kuswanto, Carissa Nadia; Sitoh, Yih Yian; De Souza, Joshua; Hong, Zhaoping; Fischl, Bruce; Roffman, Joshua L.; Zhou, Juan; Sim, Kang; Holt, Daphne J. (2016)
      Volume deficits of the hippocampus in schizophrenia have been consistently reported. However, the hippocampus is anatomically heterogeneous; it remains unclear whether certain portions of the hippocampus are affected more ...

    • Regional White Matter Volume Differences in Nondemented Aging and Alzheimer's Disease 

      Salat, David; Greve, Douglas; Pacheco, Jennifer; Quinn, Brian T.; Helmer, Karl; Buckner, Randy; Fischl, Bruce (Elsevier, 2009)
      Accumulating evidence suggests that altered cerebral white matter (WM) influences normal aging, and further that WM degeneration may modulate the clinical expression of Alzheimer's disease (AD). Here we conducted a study ...

    • Selective Disruption of the Cerebral Neocortex in Alzheimer's Disease 

      Desikan, Rahul S.; Schmansky, Nicholas J.; Cabral, Howard J.; Hess, Christopher P.; Weiner, Michael W.; Kemper, Thomas L.; Dale, Anders M.; Sabuncu, Mert R; the Alzheimer’s Disease Neuroimaging Initiative; Reuter, Martin; Biffi, Alessandro; Anderson, Christopher David; Rosand, Jonathan; Salat, David H.; Sperling, Reisa Anne; Fischl, Bruce R. (Public Library of Science, 2010)
      Background: Alzheimer's disease (AD) and its transitional state mild cognitive impairment (MCI) are characterized by amyloid plaque and tau neurofibrillary tangle (NFT) deposition within the cerebral neocortex and neuronal ...

    • Tracking the Roots of Reading Ability: White Matter Volume and Integrity Correlate with Phonological Awareness in Prereading and Early-Reading Kindergarten Children 

      Saygin, Z. M.; Norton, E. S.; Osher, D. E.; Beach, S. D.; Cyr, A. B.; Ozernov-Palchik, O.; Yendiki, Anastasia; Fischl, Bruce R.; Gaab, Nadine; Gabrieli, John D.E. (Society for Neuroscience, 2013)
      Developmental dyslexia, an unexplained difficulty in learning to read, has been associated with alterations in white matter organization as measured by diffusion-weighted imaging. It is unknown, however, whether these ...

    • Transcriptional Landscape of the Prenatal Human Brain 

      Miller, Jeremy A.; Ding, Song-Lin; Sunkin, Susan M.; Smith, Kimberly A; Ng, Lydia; Szafer, Aaron; Ebbert, Amanda; Riley, Zackery L.; Aiona, Kaylynn; Arnold, James M.; Bennet, Crissa; Bertagnolli, Darren; Brouner, Krissy; Butler, Stephanie; Caldejon, Shiella; Carey, Anita; Cuhaciyan, Christine; Dalley, Rachel A.; Dee, Nick; Dolbeare, Tim A.; Facer, Benjamin A. C.; Feng, David; Fliss, Tim P.; Gee, Garrett; Goldy, Jeff; Gourley, Lindsey; Gregor, Benjamin W.; Gu, Guangyu; Howard, Robert E.; Jochim, Jayson M.; Kuan, Chihchau L.; Lau, Christopher; Lee, Chang-Kyu; Lee, Felix; Lemon, Tracy A.; Lesnar, Phil; McMurray, Bergen; Mastan, Naveed; Mosqueda, Nerick F.; Naluai-Cecchini, Theresa; Ngo, Nhan-Kiet; Nyhus, Julie; Oldre, Aaron; Olson, Eric; Parente, Jody; Parker, Patrick D.; Parry, Sheana E.; Player, Allison Stevens; Pletikos, Mihovil; Reding, Melissa; Royall, Joshua J.; Roll, Kate; Sandman, David; Sarreal, Melaine; Shapouri, Sheila; Shapovalova, Nadiya V.; Shen, Elaine H.; Sjoquist, Nathan; Slaughterbeck, Clifford R.; Smith, Michael; Sodt, Andy J.; Williams, Derric; Zöllei, Lilla; Fischl, Bruce; Gerstein, Mark B.; Geschwind, Daniel H.; Glass, Ian A.; Hawrylycz, Michael J.; Hevner, Robert F.; Huang, Hao; Jones, Allan R.; Knowles, James A.; Levitt, Pat; Phillips, John W.; Sestan, Nenad; Wohnoutka, Paul; Dang, Chinh; Bernard, Amy; Hohmann, John G.; Lein, Ed S. (2014)
      Summary The anatomical and functional architecture of the human brain is largely determined by prenatal transcriptional processes. We describe an anatomically comprehensive atlas of mid-gestational human brain, including ...

    • Unsupervised Medical Image Segmentation Based on the Local Center of Mass 

      Aganj, Iman; Harisinghani, Mukesh; Weissleder, Ralph; Fischl, Bruce (Springer Science and Business Media LLC, 2018-08-29)
      Image segmentation is a critical step in numerous medical imaging studies, which can be facilitated by automatic computational techniques. Supervised methods, although highly effective, require large training datasets of ...