Browsing by Author "Suh MacIntosh, Helen H."
Now showing items 1-17 of 17
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Air conditioning and source-specific particles as modifiers of the effect of PM(10) on hospital admissions for heart and lung disease.
Janssen, Nicole A H; Schwartz, Joel David; Zanobetti, Antonella; Suh MacIntosh, Helen H. (National Institute of Environmental Health Sciences, 2002)Studies on acute effects of particulate matter (PM) air pollution show significant variability in exposure-effect relations among cities. Recent studies have shown an influence of ventilation on personal/indoor-outdoor ... -
Air Pollution and ST-Segment Depression in Elderly Subjects
MacCallum, Gail; Canner, Marina J.; Gold, Diane R.; Litonjua, Augusto Ampil; Zanobetti, Antonella; Coull, Brent Andrew; Schwartz, Joel David; Verrier, Richard Leonard; Nearing, Bruce David; Suh MacIntosh, Helen H.; Stone, Peter Howard (National Institue of Environmental Health Sciences, 2005)Increased levels of daily ambient particle pollution have been associated with increased risk of cardiovascular morbidity. Black carbon (BC) is a measure of the traffic-related component of particles. We investigated ... -
Ambient and Microenvironmental Particles and Exhaled Nitric Oxide Before and After a Group Bus Trip
Adar, Sara Dubowsky; Adamkiewicz, Gary; Gold, Diane R.; Schwartz, Joel David; Coull, Brent Andrew; Suh MacIntosh, Helen H. (National Institute of Environmental Health Sciences, 2007)Objectives: Airborne particles have been linked to pulmonary oxidative stress and inflammation. Because these effects may be particularly great for traffic-related particles, we examined associations between particle ... -
Annual Ambient Black Carbon Associated with Shorter Telomeres in Elderly Men: Veterans Affairs Normative Aging Study
Hoxha, Mirjam; Dioni, Laura; McCracken, John Patrick; Baccarelli, Andrea; Melly, Steven John; Coull, Brent Andrew; Suh MacIntosh, Helen H.; Vokonas, Pantel S; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2010)Background: Telomere length reflects biological age and is inversely associated with risk of cardiovascular disease (CVD). Ambient air pollution is associated with CVD, but its effect on telomere length is unknown. Objective: ... -
Black Carbon Exposure, Oxidative Stress Genes, and Blood Pressure in a Repeated-measures Study
Mordukhovich, Irina; Wilker, Elissa Hope; Suh MacIntosh, Helen H.; Wright, Robert O.; Sparrow, David; Vokonas, Pantel S; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2009)Background: Particulate matter (PM) air pollution has been associated with cardiovascular morbidity and mortality, and elevated blood pressure (BP) is a known risk factor for cardiovascular disease. A small number of studies ... -
Black Carbon Exposures, Blood Pressure, and Interactions with Single Nucleotide Polymorphisms in MicroRNA Processing Genes
Wilker, Elissa Hope; Baccarelli, Andrea; Suh MacIntosh, Helen H.; Vokonas, Pantel S; Wright, Robert O.; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2010)Background: Black carbon (BC) is a marker of traffic pollution that has been associated with blood pressure (BP), but findings have been inconsistent. MicroRNAs (miRNAs) are emerging as key regulators of gene expression, ... -
Chronic Fine and Coarse Particulate Exposure, Mortality, and Coronary Heart Disease in the Nurses’ Health Study
Puett, Robin C.; Yanosky, Jeff D; Hart, Jaime Elizabeth; Paciorek, Christopher Joseph; Schwartz, Joel David; Suh MacIntosh, Helen H.; Speizer, Frank Erwin; Laden, Francine (National Institute of Environmental Health Sciences, 2009)Background: The relationship of fine particulate matter < 2.5 μm in diameter (PM2.5) air pollution with mortality and cardiovascular disease is well established, with more recent long-term studies reporting larger effect ... -
Effect Modification of Air Pollution on Urinary 8-Hydroxy-2'-Deoxyguanosine by Genotypes: An Application of the Multiple Testing Procedure to Identify Significant SNP Interactions
Ren, Cizao; Vokonas, Pantel S; Suh MacIntosh, Helen H.; Fang, Shona C.; Christiani, David C.; Schwartz, Joel David (BioMed Central, 2010)Background: Air pollution is associated with adverse human health, but mechanisms through which pollution exerts effects remain to be clarified. One suggested pathway is that pollution causes oxidative stress. If so, ... -
Effects of Ambient Air Pollution on Functional Status in Patients with Chronic Congestive Heart Failure: a Repeated-Measures Study
Wellenius, Gregory A.; Yeh, Gloria Y.; Coull, Brent Andrew; Suh MacIntosh, Helen H.; Phillips, Russell Scott; Mittleman, Murray A. (BioMed Central, 2007)Background: Studies using administrative data report a positive association between ambient air pollution and the risk of hospitalization for congestive heart failure (HF). Circulating levels of B-type natriuretic peptide ... -
Factors Affecting the Association between Ambient Concentrations and Personal Exposures to Particles and Gases
Sarnat, Stefanie Ebelt; Coull, Brent Andrew; Schwartz, Joel David; Gold, Diane R.; Suh MacIntosh, Helen H. (National Institute of Environmental Health Sciences, 2005)Results from air pollution exposure assessment studies suggest that ambient fine particles [particulate matter with aerodynamic diameter ≤ 2.5 μg (PM2.5)], but not ambient gases, are strong proxies of corresponding personal ... -
A Novel Genetic Score Approach Using Instruments to Investigate Interactions between Pathways and Environment: Application to Air Pollution
Bind, Marie-Abele; Coull, Brent; Suh, Helen; Wright, Robert; Baccarelli, Andrea; Vokonas, Pantel; Schwartz, Joel (Public Library of Science, 2014)Air pollution has been associated with increased systemic inflammation markers. We developed a new pathway analysis approach to investigate whether gene variants within relevant pathways (oxidative stress, endothelial ... -
Opposing Effects of Particle Pollution, Ozone, and Ambient Temperature on Arterial Blood Pressure
Luttmann-Gibson, Heike; de Souza, Celine; Foley, Christopher; Hoffmann, Barbara H.; Cohen, Allison Leigh; Zanobetti, Antonella; Suh MacIntosh, Helen H.; Coull, Brent Andrew; Schwartz, Joel David; Mittleman, Murray A.; Stone, Peter Howard; Horton, Edward S.; Gold, Diane R. (National Institute of Environmental Health Sciences, 2012)Background: Diabetes increases the risk of hypertension and orthostatic hypotension and raises the risk of cardiovascular death during heat waves and high pollution episodes. Objective: We examined whether short-term ... -
Particulate air pollution, oxidative stress genes, and heart rate variability in an elderly cohort
Chahine, Teresa; Baccarelli, Andrea; Litonjua, Augusto Ampil; Wright, Robert O.; Suh MacIntosh, Helen H.; Gold, Diane R.; Sparrow, David; Vokonas, Pantel S; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2007)Background and Objectives: We have previously shown that reduced defenses against oxidative stress due to glutathione S-transferase M1 (GSTM1) deletion modify the effects of PM[2.5] (fine-particulate air pollution of < 2.5 ... -
Predicting Chronic Fine and Coarse Particulate Exposures Using Spatiotemporal Models for the Northeastern and Midwestern United States
Yanosky, Jeff D.; Suh MacIntosh, Helen H.; Paciorek, Christopher Joseph (National Institute of Environmental Health Sciences, 2008)Background: Chronic epidemiologic studies of particulate matter (PM) are limited by the lack of monitoring data, relying instead on citywide ambient concentrations to estimate exposures. This method ignores within-city ... -
Reduction in Heart Rate Variability with Traffic and Air Pollution in Patients with Coronary Artery Disease
Zanobetti, Antonella; Gold, Diane R.; Stone, Peter Howard; Suh MacIntosh, Helen H.; Schwartz, Joel David; Coull, Brent Andrew; Speizer, Frank Erwin (National Institute of Environmental Health Sciences, 2009)Introduction: Ambient particulate pollution and traffic have been linked to myocardial infarction and cardiac death risk. Possible mechanisms include autonomic cardiac dysfunction. Methods: In a repeated-measures study of ... -
The Relationship Between Ambient Air Pollution and Heart Rate Variability Differs for Individuals with Heart and Pulmonary Disease
Wheeler, Amanda; Zanobetti, Antonella; Gold, Diane R.; Schwartz, Joel David; Stone, Peter Howard; Suh MacIntosh, Helen H. (National Institute of Environmental Health Sciences, 2005)Associations between concentrations of ambient fine particles [particulate matter < 2.5 μm aerodynamic diameter (PM\(_{2.5}\))] and heart rate variability (HRV) have differed by study population. We examined the effects ... -
Workgroup Report: Workshop on Source Apportionment of Particulate Matter Health Effects—Intercomparison of Results and Implications
Thurston, George D.; Ito, Kazuhiko; Mar, Therese; Christensen, William F.; Eatough, Delbert J.; Henry, Ronald C.; Lall, Ramona; Larson, Timothy V.; Neas, Lucas; Pinto, Joseph; Stölzel, Matthias; Hopke, Philip K.; Kim, Eugene; Laden, Francine; Liu, Hao; Suh MacIntosh, Helen H. (National Institute of Environmental Health Sciences, 2005)Although the association between exposure to ambient fine particulate matter with aerodynamic diameter < 2.5 μm (PM\(_{2.5}\)) and human mortality is well established, the most responsible particle types/sources are not ...