Browsing FAS Scholarly Articles by FAS Department "Molecular and Cellular Biology"
Now showing items 21-40 of 400
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Atomic Layer Deposition to Fine-Tune the Surface Properties and Diameters of Fabricated Nanopores
(American Chemical Society, 2004)Atomic layer deposition of alumina enhanced the molecule sensing characteristics of fabricated nanopores by fine-tuning their surface properties, reducing 1/f noise, neutralizing surface charge to favor capture of DNA and ... -
Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise
(Proceedings of the National Academy of Sciences, 2010)The cellular basis of age-related behavioral decline remains obscure but alterations in synapses are likely candidates. Accordingly, the beneficial effects on neural function of caloric restriction and exercise, which are ... -
Attenuation of Notch and Hedgehog Signaling Is Required for Fate Specification in the Spinal Cord
(Public Library of Science, 2012)During the development of the spinal cord, proliferative neural progenitors differentiate into postmitotic neurons with distinct fates. How cells switch from progenitor states to differentiated fates is poorly understood. ... -
Automatic Categorization of Diverse Experimental Information in the Bioscience Literature
(BioMed Central, 2012)Background: Curation of information from bioscience literature into biological knowledge databases is a crucial way of capturing experimental information in a computable form. During the biocuration process, a critical ... -
Base Dependent DNA-carbon Nanotube Interactions: Activation Enthalpies and Assembly-disassembly Control
(Institute of Physics, 2009)We quantify the base dependent interactions between single stranded DNA and single walled carbon nanotubes (SWNTs) in solution. DNA/SWNT hybrids hold the promise of applications ranging from nanoscale electronics and ... -
Batrachotoxin acts as a stent to hold open homotetrameric prokaryotic voltage-gated sodium channels
(Rockefeller University Press, 2018-12-26)Batrachotoxin (BTX), an alkaloid from skin secretions of dendrobatid frogs, causes paralysis and death by facilitating activation and inhibiting deactivation of eukaryotic voltage-gated sodium (Nav) channels, which underlie ... -
Bayesian approach to single-cell differential expression analysis
(Springer Nature, 2014)Single-cell data provide a means to dissect the composition of complex tissues and specialized cellular environments. However, the analysis of such measurements is complicated by high levels of technical noise and intrinsic ... -
Bayesian Model of Dynamic Image Stabilization in the Visual System
(Proceedings of the National Academy of Sciences, 2010)Humans can resolve the fine details of visual stimuli although the image projected on the retina is constantly drifting relative to the photoreceptor array. Here we demonstrate that the brain must take this drift into ... -
The Big and the Small: Challenges of Imaging the Brain's Circuits
(American Association for the Advancement of Science (AAAS), 2011)The relation between the structure of the nervous system and its function is more poorly understood than the relation between structure and function in any other organ system. We explore why bridging the structure-function ... -
The Big Data Problem: Turning Maps into Knowledge
(Elsevier BV, 2014)In this NeuroView, Engert discusses the challenges for the connectomics field in making insights about brain function from big data. -
Bilayer Mechanical Properties Regulate Transmembrane Helix Mobility and Enzymatic State of CD39
(American Chemical Society, 2005)CD39 can exist in at least two distinct functional states depending on the presence and intact membrane integration of its two transmembrane helices. In native membranes, the transmembrane helices undergo dynamic rotational ... -
Bilingual neurons release glutamate and GABA
(Nature Publishing Group, 2014)A study finds evidence supporting co-release of glutamate and GABA, excitatory and inhibitory fast neurotransmitters, from a single axon terminal in neurons of the ventral tegmental area that project to the lateral habenula. -
A Biochemically Active MCM-like Helicase in Bacillus Cereus
(Oxford University Press, 2009)The mini-chromosome maintenance (MCM) proteins serve as the replicative helicases in archaea and eukaryotes. Interestingly, an MCM homolog was identified, by BLAST analysis, within a phage integrated in the bacterium ... -
Brain Function and Chromatin Plasticity
(Nature Publishing Group, 2010)The characteristics of epigenetic control, including the potential for long-lasting, stable effects on gene expression that outlive an initial transient signal, could be of singular importance for post-mitotic neurons, ... -
Calcium Dynamics During Fertilization in C. elegans
(BioMed Central, 2001)Background: Of the animals typically used to study fertilization-induced calcium dynamics, none is as accessible to genetics and molecular biology as the model organism Caenorhabditis elegans. Motivated by the experimental ... -
Cancer proliferation and therapy: the Warburg effect and quantum metabolism
(BioMed Central, 2010)Background: Most cancer cells, in contrast to normal differentiated cells, rely on aerobic glycolysis instead of oxidative phosphorylation to generate metabolic energy, a phenomenon called the Warburg effect. Model: Quantum ... -
Cavitation in Linear Bubbles
(Cambridge University Press, 2009)Recent work has developed a beautiful model system for studying the energy focusing and heating power of collapsing bubbles. The bubble is effectively one-dimensional and the collapse and heating can be quantitatively ... -
CD8+ T Cells Restrict Yersinia pseudotuberculosis Infection: Bypass of Anti-Phagocytosis by Targeting Antigen-Presenting Cells
(Public Library of Science, 2009)All Yersinia species target and bind to phagocytic cells, but uptake and destruction of bacteria are prevented by injection of anti-phagocytic Yop proteins into the host cell. Here we provide evidence that CD8+ T cells, ... -
The cdx Genes and Retinoic Acid Control the Positioning and Segmentation of the Zebrafish Pronephros
(Public Library of Science, 2007)Kidney function depends on the nephron, which comprises a blood filter, a tubule that is subdivided into functionally distinct segments, and a collecting duct. How these regions arise during development is poorly understood. ... -
Cell Division Cycle 6, a Mitotic Substrate of Polo-Like Kinase 1, Regulates Chromosomal Segregation Mediated by Cyclin-Dependent Kinase 1 and Separase
(Proceedings of the National Academy of Sciences, 2010)Defining the links between cell division and DNA replication is essential for understanding normal cell cycle progression and tumorigenesis. In this report we explore the effect of phosphorylation of cell division cycle 6 ...