Browsing Harvard Medical School by Title
Now showing items 7205-7224 of 18465
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Genome-wide association study of endometrial cancer in E2C2
(Springer Berlin Heidelberg, 2013)Endometrial cancer (EC), a neoplasm of the uterine epithelial lining, is the most common gynecological malignancy in developed countries and the fourth most common cancer among US women. Women with a family history of EC ... -
Genome-Wide Association Study of Human Immunodeficiency Virus (HIV)-1 Coreceptor Usage in Treatment-Naive Patients from An AIDS Clinical Trials Group Study
(Oxford University Press, 2014)Objectives. We conducted a genome-wide association study to explore whether common host genetic variants (>5% frequency) were associated with presence of virus able to use CXCR4 for entry. Methods. Phenotypic determination ... -
Genome-wide association study of kidney function decline in individuals of European descent
(2014)Genome wide association studies (GWAS) have identified multiple loci associated with cross-sectional eGFR, but a systematic genetic analysis of kidney function decline over time is missing. Here we conducted a GWAS ... -
A genome-wide association study of kynurenic acid in cerebrospinal fluid: implications for psychosis and cognitive impairment in bipolar disorder
(2016)Elevated cerebrospinal fluid (CSF) levels of the glia-derived N-methyl-D-aspartic acid receptor antagonist kynurenic acid (KYNA) have consistently been implicated in schizophrenia and bipolar disorder. Here, we conducted ... -
Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium
(Nature Publishing Group, 2016)Cannabis is the most widely produced and consumed illicit psychoactive substance worldwide. Occasional cannabis use can progress to frequent use, abuse and dependence with all known adverse physical, psychological and ... -
Genome-Wide Association Study of Major Depressive Disorder: New Results, Meta-Analysis, and Lessons Learned
(Nature Publishing Group, 2012)Major depressive disorder (MDD) is a common complex disorder with a partly genetic etiology. We conducted a genome-wide association study of the MDD2000+ sample (2431 cases, 3673 screened controls and >1 M imputed ... -
A genome-wide association study of marginal zone lymphoma shows association to the HLA region
(Nature Pub. Group, 2015)Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci ... -
A Genome-Wide Association Study of Pulmonary Function Measures in the Framingham Heart Study
(Public Library of Science, 2009)The ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC) is a measure used to diagnose airflow obstruction and is highly heritable. We performed a genome-wide association study in 7,691 ... -
Genome-Wide Association Study of Retinopathy in Individuals Without Diabetes
(Public Library of Science, 2013)Background: Mild retinopathy (microaneurysms or dot-blot hemorrhages) is observed in persons without diabetes or hypertension and may reflect microvascular disease in other organs. We conducted a genome-wide association ... -
Genome-wide association study of shared components of reading disability and language impairment
(Blackwell Publishing Ltd, 2013)Written and verbal languages are neurobehavioral traits vital to the development of communication skills. Unfortunately, disorders involving these traits—specifically reading disability (RD) and language impairment (LI)—are ... -
Genome-wide association study of subtype-specific epithelial ovarian cancer risk alleles using pooled DNA
(Springer Science + Business Media, 2013)Epithelial ovarian cancer (EOC) is a heterogeneous cancer with both genetic and environmental risk factors. Variants influencing the risk of developing the less-common EOC subtypes have not been fully investigated. We ... -
Genome-wide association study of susceptibility loci for breast cancer in Sardinian population
(BioMed Central, 2015)Background: Despite progress in identifying genes associated with breast cancer, many more risk loci exist. Genome-wide association analyses in genetically-homogeneous populations, such as that of Sardinia (Italy), could ... -
Genome-wide association study of Tourette Syndrome
(2012)Tourette Syndrome (TS) is a developmental disorder that has one of the highest familial recurrence rates among neuropsychiatric diseases with complex inheritance. However, the identification of definitive TS susceptibility ... -
Genome-wide association study on serum alkaline phosphatase levels in a Chinese population
(BioMed Central, 2013)Background: Serum alkaline phosphatase (ALP) is a complex phenotype influenced by both genetic and environmental factors. Recent Genome-Wide Association Studies (GWAS) have identified several loci affecting ALP levels; ... -
A Genome-Wide Association Study Reveals Variants in ARL15 that Influence Adiponectin Levels
(Public Library of Science, 2009)The adipocyte-derived protein adiponectin is highly heritable and inversely associated with risk of type 2 diabetes mellitus (T2D) and coronary heart disease (CHD). We meta-analyzed 3 genome-wide association studies for ... -
Genome-Wide Association with Bone Mass and Geometry in the Framingham Heart Study
(BioMed Central, 2007)Background: Osteoporosis is characterized by low bone mass and compromised bone structure, heritable traits that contribute to fracture risk. There have been no genome-wide association and linkage studies for these traits ... -
Genome-Wide Association with Diabetes-Related Traits in the Framingham Heart Study
(BioMed Central, 2007)Background: Susceptibility to type 2 diabetes may be conferred by genetic variants having modest effects on risk. Genome-wide fixed marker arrays offer a novel approach to detect these variants. Methods: We used the ... -
Genome-wide Co-occurrence of Promoter Elements Reveals a cis-Regulatory Cassette of rRNA Transcription Motifs in Saccharomyces cerevisiae
(Cold Spring Harbor Laboratory, 2002-11-01)Combinatorial regulation is an important feature of eukaryotic transcription. However, only a limited number of studies have characterized this aspect on a whole-genome level. We have conducted a genome-wide computational ... -
Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia
(2016)The antipsychotic clozapine is uniquely effective in the management of schizophrenia, but its use is limited by its potential to induce agranulocytosis. The causes of this, and of its precursor neutropenia, are largely ... -
Genome-wide comparison of DNA hydroxymethylation in mouse embryonic stem cells and neural progenitor cells by a new comparative hMeDIP-seq method
(Oxford University Press, 2013)The genome-wide distribution patterns of the ‘6th base’ 5-hydroxymethylcytosine (5hmC) in many tissues and cells have recently been revealed by hydroxymethylated DNA immunoprecipitation (hMeDIP) followed by high throughput ...