Browsing Harvard Medical School by Title
Now showing items 7663-7682 of 18433
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Hemopexin in severe inflammation and infection: mouse models and human diseases
(BioMed Central, 2015)Introduction: Cell-free plasma hemoglobin is associated with poor outcome in patients with sepsis. Extracellular hemoglobin and secondarily released heme amplify inflammation in the presence of microbial TLR ligands and/or ... -
Hemorrhage After Manual Removal of the Placenta: Weighing Risk Factors and the Role of the Third Stage of Labor
(2018-05-15)Introduction: Manual removal of the placenta, often due to uterine atony or an abnormally adherent placenta, can be accompanied by severe maternal postpartum hemorrhage. The objective of this study was to identify risk ... -
Hemorrhage from Extra-Antral Gastric Antral Vascular Ectasia in a Patient with Duodenal Heterotopic Gastric Mucosa
(Hindawi Publishing Corporation, 2016)Gastric antral vascular ectasias (GAVE) have been increasingly recognized as an uncommon cause of chronic gastrointestinal bleeding and anemia, although their underlying pathogenesis is not completely well understood. ... -
Hemorrhagic Stroke Probably Caused by Exercise Combined With a Sports Supplement Containing β-Methylphenyl-ethylamine (BMPEA): A Case Report
(American College of Physicians, 2015-06-16) -
Heparan Sulfate Regrowth Profiles Under Laminar Shear Flow Following Enzymatic Degradation
(Springer US, 2013)The local hemodynamic shear stress waveforms present in an artery dictate the endothelial cell phenotype. The observed decrease of the apical glycocalyx layer on the endothelium in atheroprone regions of the circulation ... -
Heparan sulphate proteoglycans: the sweet side of development
(Nature Research (part of Springer Nature), 2005)Pattern formation during development is controlled to a great extent by a small number of conserved signal transduction pathways that are activated by extracellular ligands such as Hedgehog, Wingless or Decapentaplegic. ... -
Heparin affinity purification of extracellular vesicles
(Nature Publishing Group, 2015)Extracellular vesicles (EVs) are lipid membrane vesicles released by cells. They carry active biomolecules including DNA, RNA, and protein which can be transferred to recipient cells. Isolation and purification of EVs from ... -
Heparin requirements for full anticoagulation are higher for patients on dabigatran than for those on warfarin – a model-based study
(Dove Medical Press, 2015)Purpose Dabigatran (D) is increasingly used for chronic anticoagulation in place of warfarin (W). These patients may present for catheter-based procedures requiring full anticoagulation with heparin. This study compares ... -
Heparin-induced cis- and trans-Dimerization Modes of the Thrombospondin-1 N-terminal Domain
(American Society for Biochemistry and Molecular Biology, 2008)Through its interactions with proteins and proteoglycans, thrombospondin-1 (TSP-1) functions at the interface of the cell membrane and the extracellular matrix to regulate matrix structure and cellular phenotype. We have ... -
Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury
(National Academy of Sciences, 2017)The neonatal crystallizable fragment receptor (FcRn) is responsible for maintaining the long half-life and high levels of the two most abundant circulating proteins, albumin and IgG. In the latter case, the protective ... -
Hepatic Injury in Nonalcoholic Steatohepatitis Contributes to Altered Intestinal Permeability
(2015)BACKGROUND & AIMS Emerging data suggest that changes in intestinal permeability and increased gut microbial translocation contribute to the inflammatory pathway involved in nonalcoholic steatohepatitis (NASH) development. ... -
Hepatic Steatosis is Associated with Lower Levels of Physical Activity Measured via Accelerometry
(2015)Objective: Prior studies on the association of physical activity (PA) and non-alcoholic fatty liver disease are limited by reliance on subjective measures of PA. We examined the association between objectively measured PA ... -
Hepatic tissue engineering: from transplantation to customized cell-based liver directed therapies from the laboratory
(Blackwell Publishing Ltd, 2008)Abstract Today, liver transplantation is still the only curative treatment for liver failure due to end-stage liver diseases. Donor organ shortage, high cost and the need of immunosuppressive medications are still the major ... -
Hepatitis B: Prevalence, Hope
(Ulster Medical Society, 2019-05) -
The Hepatitis C Cascade of Care: Identifying Priorities to Improve Clinical Outcomes
(Public Library of Science, 2014)Background: As highly effective hepatitis C virus (HCV) therapies emerge, data are needed to inform the development of interventions to improve HCV treatment rates. We used simulation modeling to estimate the impact of ... -
Hepatitis C Virus and Hepatocarcinogenesis
(The Korean Association for the Study of the Liver, 2012)Hepatitis C virus (HCV) is an RNA virus that is unable to integrate into the host genome. However, its proteins interact with various host proteins and induce host responses. The oncogenic process of HCV infection is slow ... -
Hepatitis C Virus Cell-Cell Transmission and Resistance to Direct-Acting Antiviral Agents
(Public Library of Science, 2014)Hepatitis C virus (HCV) is transmitted between hepatocytes via classical cell entry but also uses direct cell-cell transfer to infect neighboring hepatocytes. Viral cell-cell transmission has been shown to play an important ... -
Hepatitis C Virus Infection Protein Network
(Nature Publishing Group, 2008)A proteome-wide mapping of interactions between hepatitis C virus (HCV) and human proteins was performed to provide a comprehensive view of the cellular infection. A total of 314 protein–protein interactions between HCV ... -
Hepatitis C virus NS3‐4A inhibits the peroxisomal MAVS‐dependent antiviral signalling response
(John Wiley and Sons Inc., 2016)Abstract Hepatitis C virus (HCV) is the cause of one of the most prevalent viral infections worldwide. Upon infection, the HCV genome activates the RIG‐I‐MAVS signalling pathway leading to the production of direct antiviral ...