Browsing HMS Scholarly Articles by Title

Now showing items 9635-9654 of 17922

    • Lifestyle‐Based Prediction Model for the Prevention of CVD: The Healthy Heart Score 

      Chiuve, Stephanie E.; Cook, Nancy R.; Shay, Christina M.; Rexrode, Kathryn M.; Albert, Christine M.; Manson, JoAnn E.; Willett, Walter C.; Rimm, Eric B. (Blackwell Publishing Ltd, 2014)
      Background: Clinical practice focuses on the primary prevention of cardiovascular (CV) disease (CVD) through the modification and pharmacological treatment of elevated risk factors. Prediction models based on established ...

    • Lifetime and 12-month prevalence of eating disorders amongst women in mid-life: a population-based study of diagnoses and risk factors 

      Micali, Nadia; Martini, Maria G.; Thomas, Jennifer J.; Eddy, Kamryn T.; Kothari, Radha; Russell, Ellie; Bulik, Cynthia M.; Treasure, Janet (BioMed Central, 2017)
      Background: Eating disorders (EDs) are common amongst women; however, no research has specifically investigated the lifetime/12-month prevalence of eating disorders amongst women in mid-life (i.e., fourth and fifth decade ...

    • Lifetime Increased Cancer Risk in Mice Following Exposure to Clinical Proton Beam–Generated Neutrons 

      Gerweck, Leo Edward; Huang, Peigen; Lu, Hsiao-ming; Paganetti, Harald; Zhou, Yenong (Elsevier BV, 2014)
      Purpose To evaluate the lifespan and risk of cancer following whole-body exposure of mice to neutrons generated by a passively scattered clinical SOBP proton beam. Methods and Materials Three hundred young adult ...

    • Lifetime Prevalence of Mental Disorders in Lebanon: First Onset, Treatment, and Exposure to War 

      Dimassi, Hani; Chatterji, Somnath; Karam, Elie G.; Mneimneh, Zeina N.; Fayyad, John A.; Karam, Aimee N.; Nasser, Soumana C.; Kessler, Ronald (Public Library of Science, 2008)
      Background: There are no published data on national lifetime prevalence and treatment of mental disorders in the Arab region. Furthermore, the effect of war on first onset of disorders has not been addressed previously ...

    • Lifetime Risk of Cardiovascular Disease Among Individuals With and Without Diabetes Stratified by Obesity Status in the Framingham Heart Study 

      Fox, Caroline; Pencina, Michael J.; Wilson, Peter W.F.; Paynter, Nina Palanza; Vasan, Ramachandran S.; D’Agostino, Ralph B. (American Diabetes Association, 2008)
      Objective: We assessed the lifetime risk of cardiovascular disease (CVD) among individuals with and without obesity and diabetes. Research Design and Methods: Participants were drawn from the original and offspring cohorts ...

    • Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1 

      Kowal, Julia; Chami, Mohamed; Baumgartner, Paul; Arheit, Marcel; Chiu, Po-Lin; Rangl, Martina; Scheuring, Simon; Schröder, Gunnar F.; Nimigean, Crina M.; Stahlberg, Henning (Nature Pub. Group, 2014)
      Cyclic nucleotide-modulated ion channels are important for signal transduction and pacemaking in eukaryotes. The molecular determinants of ligand gating in these channels are still unknown, mainly because of a lack of ...

    • Ligation of the Jugular Veins Does Not Result in Brain Inflammation or Demyelination in Mice 

      Atkinson, Wendy; Forghani, Reza; Wojtkiewicz, Gregory R.; Pulli, Benjamin; Iwamoto, Yoshiko; Ueno, Takuya; Waterman, Peter; Truelove, Jessica; Oklu, Rahmi; Chen, John Wen-Yueh (Public Library of Science, 2012)
      An alternative hypothesis has been proposed implicating chronic cerebrospinal venous insufficiency (CCSVI) as a potential cause of multiple sclerosis (MS). We aimed to evaluate the validity of this hypothesis in a controlled ...

    • Light Controlled Modulation of Gene Expression by Chemical Optoepigenetic Probes 

      Reis, Surya A.; Ghosh, Balaram; Hendricks, J. Adam; Szantai-Kis, D. Miklos; Törk, Lisa; Ross, Kenneth N.; Lamb, Justin; Read-Button, Willis; Zheng, Baixue; Wang, Hongtao; Salthouse, Christopher; Haggarty, Stephen J.; Mazitschek, Ralph (2016)
      Epigenetic gene regulation is a dynamic process orchestrated by chromatin-modifying enzymes. Many of these master regulators exert their function through covalent modification of DNA and histone proteins. Aberrant epigenetic ...

    • Light to moderate intake of alcohol, drinking patterns, and risk of cancer: results from two prospective US cohort studies 

      Cao, Yin; Willett, Walter C; Rimm, Eric B; Stampfer, Meir J; Giovannucci, Edward L (BMJ Publishing Group Ltd., 2015)
      Objectives: To quantify risk of overall cancer across all levels of alcohol consumption among women and men separately, with a focus on light to moderate drinking and never smokers; and assess the influence of drinking ...

    • A light-controlled switch after dual targeting of proliferating tumor cells via the membrane receptor EGFR and the nuclear protein Ki-67 

      Wang, Sijia; Hüttmann, Gereon; Scholzen, Thomas; Zhang, Zhenxi; Vogel, Alfred; Hasan, Tayyaba; Rahmanzadeh, Ramtin (Nature Publishing Group, 2016)
      Using nanotechnology for optical manipulation of molecular processes in cells with high spatial and temporal precision promises new therapeutic options. Especially tumor therapy may profit as it requires a combination of ...

    • Light-guiding hydrogels for cell-based sensing and optogenetic synthesis in vivo 

      Choi, Myunghwan; Choi, Jin Woo; Kim, Seonghoon; Nizamoglu, Sedat; Hahn, Sei Kwang; Yun, Seok Hyun (2013)
      Polymer hydrogels are widely used as cell scaffolds for biomedical applications. While the biochemical and biophysical properties of hydrogels have been extensively investigated, little attention has been paid to their ...

    • LILRB2 Interaction with HLA Class I Correlates with Control of HIV-1 Infection 

      Bashirova, Arman A.; Martin-Gayo, Enrique; Jones, Des C.; Qi, Ying; Apps, Richard; Gao, Xiaojiang; Burke, Patrick S.; Taylor, Craig J.; Rogich, Jerome; Wolinsky, Steven; Bream, Jay H.; Duggal, Priya; Hussain, Shehnaz; Martinson, Jeremy; Weintrob, Amy; Kirk, Gregory D.; Fellay, Jacques; Buchbinder, Susan P.; Goedert, James J.; Deeks, Steven G.; Pereyra, Florencia; Trowsdale, John; Lichterfeld, Mathias; Telenti, Amalio; Walker, Bruce D.; Allen, Rachel L.; Carrington, Mary; Yu, Xu G. (Public Library of Science, 2014)
      Natural progression of HIV-1 infection depends on genetic variation in the human major histocompatibility complex (MHC) class I locus, and the CD8+ T cell response is thought to be a primary mechanism of this effect. ...

    • Limb regeneration revisited 

      Whited, Jessica LaMae; Tabin, Clifford James (BioMed Central, 2009)
      The investigation of vertebrate limb regeneration, a favorite topic of early developmental biologists, is enjoying a renaissance thanks to recently developed molecular and genetic tools, as indicated in recent papers in ...

    • The Limbic-Prefrontal Network Modulated by Electroacupuncture at CV4 and CV12 

      Fang, Jiliang; Zhou, Kehua; Hong, Yang; Wang, Lei; Xue, Chao; Liu, Baoyan; Wang, Xiaoling; Liu, Hesheng; Wang, Yin; Liu, Jun; Song, Ming; Zhu, Bing (Hindawi Publishing Corporation, 2012)
      fMRI studies showed that acupuncture could induce hemodynamic changes in brain networks. Many of these studies focused on whether specific acupoints could activate specific brain regions and were often limited to manual ...

    • Limitations of Current GABA Agonists in Neonatal Seizures: Toward GABA Modulation Via the Targeting of Neuronal Cl− Transport 

      Khanna, Arjun; Walcott, Brian Patrick; Kahle, Kristopher T. (Frontiers Media S.A., 2013)
      Neonatal intensive care has advanced rapidly in the last 40 years, with dramatic decreases in mortality and morbidity; however, for neonatal seizures, neither therapies nor outcomes have changed significantly. Basic and ...

    • Limitations of Keratoplasty in China: A Survey Analysis 

      Hong, Jiaxu; Shi, Weiyun; Liu, Zuguo; Pineda, Roberto; Cui, Xinhan; Sun, Xinghuai; Xu, Jianjiang (Public Library of Science, 2015)
      Purpose Each year, over 8,000 corneal transplantation surgeries are performed in China. Unlike developed countries, which have established standard requirements for operative experience for corneal specialists, little ...

    • The limitations of qPCR telomere length measurement in diagnosing dyskeratosis congenita 

      Gadalla, Shahinaz M.; Khincha, Payal P.; Katki, Hormuzd A.; Giri, Neelam; Wong, Jason Y. Y.; Spellman, Stephen; Yanovski, Jack A.; Han, Joan C.; De Vivo, Immaculata; Alter, Blanche P.; Savage, Sharon A. (John Wiley and Sons Inc., 2016)
      Abstract Background: Telomere length <1st percentile‐for‐age in leukocyte subsets by flow cytometry with fluorescence in situ hybridization (flow FISH) is highly sensitive and specific in diagnosing patients with dyskeratosis ...

    • Limitations of the Millennium Development Goals: a literature review 

      Fehling, Maya; Nelson, Brett D.; Venkatapuram, Sridhar (Taylor & Francis, 2013)
      With the Millennium Development Goals (MDGs) showing uneven progress, this review identifies possible limitations arising from the MDG framework itself rather than extrinsic issues. A multidisciplinary literature review ...

    • Limited Awareness and Low Immediate Uptake of Pre-Exposure Prophylaxis among Men Who Have Sex with Men Using an Internet Social Networking Site 

      Krakower, Douglas S.; Mimiaga, Matthew James; Rosenberger, Joshua G.; Novak, David S.; Mitty, Jennifer A.; White, Jaclyn M.; Mayer, Kenneth Hugh (Public Library of Science, 2012)
      Background: In 2010, the iPrEx trial demonstrated that oral antiretroviral pre-exposure prophylaxis (PrEP) reduced the risk of HIV acquisition among high-risk men who have sex with men (MSM). The impact of iPrEx on PrEP ...

    • Limited English Proficient Patients and Time Spent in Therapeutic Range in a Warfarin Anticoagulation Clinic 

      Rodriguez, Fátima; Hong, Clemens; Chang, Yuchiao; Oertel, Lynn B.; Singer, Daniel E.; Green, Alexander R.; López, Lenny (Blackwell Publishing Ltd, 2013)
      Background: While anticoagulation clinics have been shown to deliver tailored, high‐quality care to patients receiving warfarin therapy, communication barriers with limited English proficient (LEP) patients may lead to ...