Browsing HMS Scholarly Articles by Title

Now showing items 249-268 of 17922

    • Accurate Whole-Genome Sequencing and Haplotyping from 10 to 20 Human Cells 

      Peters, Brock A.; Kermani, Bahram G.; Sparks, Andrew B.; Alferov, Oleg; Hong, Peter; Alexeev, Andrei; Jiang, Yuan; Dahl, Fredrik; Tang, Y. Tom; Haas, Juergen; Robasky, Kimberly J.; Lee, Je-Hyuk; Peterson, Joseph E.; Perazich, Helena; Yeung, George; Liu, Jia; Chen, Linsu; Kennemer, Michael I.; Pothuraju, Kaliprasad; Konvicka, Karel; Tsoupko-Sitnikov, Mike; Pant, Krishna P.; Ebert, Jessica C.; Nilsen, Geoffrey B.; Baccash, Jonathan; Halpern, Aaron L.; Church, George McDonald; Drmanac, Radoje; Zaranek, Alexander Wait; Ball, Madeleine Price (Nature Publishing Group, 2012)
      Recent advances in whole genome sequencing have brought the vision of personal genomics and genomic medicine closer to reality. However, current methods lack clinical accuracy and the ability to describe the context ...

    • Acellular Bi-Layer Silk Fibroin Scaffolds Support Tissue Regeneration in a Rabbit Model of Onlay Urethroplasty 

      Chung, Yeun Goo; Tu, Duong; Franck, Debra; Gil, Eun Seok; Algarrahi, Khalid; Adam, Rosalyn M.; Kaplan, David L.; Estrada Jr., Carlos R.; Mauney, Joshua R. (Public Library of Science, 2014)
      Acellular scaffolds derived from Bombyx mori silk fibroin were investigated for their ability to support functional tissue regeneration in a rabbit model of urethra repair. A bi-layer silk fibroin matrix was fabricated by ...

    • Acellular Dermal Matrix in Reconstructive Breast Surgery: Survey of Current Practice among Plastic Surgeons 

      Ibrahim, Ahmed M. S.; Koolen, Pieter G. L.; Ashraf, Azra A.; Kim, Kuylhee; Mureau, Marc A. M.; Lee, Bernard T.; Lin, Samuel J. (Wolters Kluwer Health, 2015)
      Background: Acellular dermal matrices (ADMs) in plastic surgery have become increasingly popular particularly for breast reconstruction. Despite their advantages, questions exist regarding their association with a possible ...

    • Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma 

      Sheehan, William; Mauger, David T.; Paul, Ian M.; Moy, James N.; Boehmer, Susan J.; Szefler, Stanley J.; Fitzpatrick, Anne M.; Jackson, Daniel J.; Bacharier, Leonard B.; Cabana, Michael D.; Covar, Ronina; Holguin, Fernando; Lemanske, Robert F.; Martinez, Fernando D.; Pongracic, Jacqueline A.; Beigelman, Avraham; Baxi, Sachin; Benson, Mindy; Blake, Kathryn; Chmiel, James F.; Daines, Cori L.; Daines, Michael O.; Gaffin, Jonathan; Gentile, Deborah A.; Gower, W. Adam; Israel, Elliot; Kumar, Harsha V.; Lang, Jason E.; Lazarus, Stephen C.; Lima, John J.; Ly, Ngoc; Marbin, Jyothi; Morgan, Wayne J.; Myers, Ross E.; Olin, J. Tod; Peters, Stephen P.; Raissy, Hengameh H.; Robison, Rachel G.; Ross, Kristie; Sorkness, Christine A.; Thyne, Shannon M.; Wechsler, Michael E.; Phipatanakul, Wanda (Massachusetts Medical Society, 2016-08-18)
      BACKGROUND Studies have suggested an association between frequent acetaminophen use and asthma-related complications among children, leading some physicians to recommend that acetaminophen be avoided in children with ...

    • Acetylation of C/EBPα inhibits its granulopoietic function 

      Bararia, Deepak; Kwok, Hui Si; Welner, Robert S.; Numata, Akihiko; Sárosi, Menyhárt B.; Yang, Henry; Wee, Sheena; Tschuri, Sebastian; Ray, Debleena; Weigert, Oliver; Levantini, Elena; Ebralidze, Alexander K.; Gunaratne, Jayantha; Tenen, Daniel G. (Nature Publishing Group, 2016)
      CCAAT/enhancer-binding protein alpha (C/EBPα) is an essential transcription factor for myeloid lineage commitment. Here we demonstrate that acetylation of C/EBPα at lysine residues K298 and K302, mediated at least in part ...

    • Acetylation-dependent regulation of essential iPS-inducing factors: a regulatory crossroad for pluripotency and tumorigenesis 

      Dai, Xiangpeng; Liu, Pengda; Lau, Alan W; Liu, Yueyong; Inuzuka, Hiroyuki (Blackwell Publishing Ltd, 2014)
      Induced pluripotent stem (iPS) cells can be generated from somatic cells by coexpression of four transcription factors: Sox2, Oct4, Klf4, and c-Myc. However, the low efficiency in generating iPS cells and the tendency of ...

    • Achieving consensus for clinical trials: The REiNS International Collaboration 

      Plotkin, Scott Randall; Blakeley, J. O.; Dombi, Eva; Fisher, Michael J.; Hanemann, C. O.; Walsh, Karin S; Wolters, P. L.; Widemann, Brigitte C. (Ovid Technologies (Wolters Kluwer Health), 2013)
      The neurofibromatoses (NF)—including neurofibromatosis 1 (NF1), neurofibromatosis 2 (NF2), and schwannomatosis—are related tumor-suppressor syndromes characterized by a predisposition to multiple tumor types and other ...

    • Achieving Goals in Geriatric Assessment: Role of Caregiver Agreement and Adherence to Recommendations 

      Inouye, Sharon; Bogardus, Sidney; Bradley, Elizabeth; Williams, Christianna; Maciejewski, Paul; Gallo, William (Wiley-Blackwell, 2004)
      Objectives: To determine predictors of recommendation adherence and goal attainment of family caregivers of patients at a geriatric assessment center. Design: One‐year prospective cohort study. Setting: Outpatient geriatric ...

    • Acid Suppression Therapy Does Not Predispose to Clostridium difficile Infection: The Case of the Potential Bias 

      Novack, Lena; Kogan, Slava; Gimpelevich, Larisa; Howell, Michael; Borer, Abraham; Kelly, Ciarán P.; Leffler, Daniel A.; Novack, Victor (Public Library of Science, 2014)
      Objective: An adverse effect of acid-suppression medications on the occurrence of Clostridium difficile infection (CDI) has been a common finding of many, but not all studies. We hypothesized that association between ...

    • The Acid Test of Fluoride: How pH Modulates Toxicity 

      Sharma, Ramaswamy Narayanaswamy; Tsuchiya, Masahiro; Skobe, Ziedonis; Tannous, Bakhos A.; Bartlett, John D. (Public Library of Science, 2010)
      Background: It is not known why the ameloblasts responsible for dental enamel formation are uniquely sensitive to fluoride (\(F^−\)). Herein, we present a novel theory with supporting data to show that the low pH environment ...

    • Acidic Extracellular pH Induces Vascular Endothelial Growth Factor (VEGF) in Human Glioblastoma Cells via ERK1/2 MAPK Signaling Pathway 

      Xu, Lei; Fukumura, Dai; Jain, Rakesh K. (American Society for Biochemistry and Molecular Biology, 2002)

    • Acidic fibroblast growth factor enhances regeneration of processes by postnatal mammalian retinal ganglion cells in culture. 

      Lipton, S. A.; Wagner, John A.; Madison, Roger D.; D'Amore, Patricia Ann (Proceedings of the National Academy of Sciences, 1988)
      Postnatal rat retinal ganglion cells (RGCs) were identified with specific fluorescent labels and placed in culture. Under these conditions, the outgrowth of processes by RGCs was found to be promoted to a far greater degree ...

    • Acid–base balance, serum electrolytes and need for non-invasive ventilation in patients with hypercapnic acute exacerbation of chronic obstructive pulmonary disease admitted to an internal medicine ward 

      Schiavo, Alfonso; Renis, Maurizio; Polverino, Mario; Iannuzzi, Arcangelo; Polverino, Francesca (BioMed Central, 2016)
      Background: Hypoventilation produces or worsens respiratory acidosis in patients with hypercapnia due to acute exacerbations of chronic obstructive pulmonary disease (AECOPD). In these patients acid–base and hydroelectrolite ...

    • Acinar Cystadenoma of the Pancreas 

      Khor, Tze S.; Badizadegan, Kamran; Ferrone, Cristina Rosa; Fernandez-Del Castillo, Carlos F.; Desai, Gaurav S.; Saenz, Adam; Le, Long Phi; Lauwers, Gregory Y.; Deshpande, Vikram (Ovid Technologies (Wolters Kluwer Health), 2012)
      Pancreatic acinar cystadenomas (ACAs) are rare cystic lesions showing acinar differentiation with benign outcome. Although debated, ACAs are favored to be neoplastic and potentially the benign counterpart of acinar ...

    • ACME: Automated Cell Morphology Extractor for Comprehensive Reconstruction of Cell Membranes 

      Mosaliganti, Kishore Rao; Noche, Ramil; Xiong, Fengzhu; Swinburne, Ian A; Megason, Sean G. (Public Library of Science, 2012)
      The quantification of cell shape, cell migration, and cell rearrangements is important for addressing classical questions in developmental biology such as patterning and tissue morphogenesis. Time-lapse microscopic imaging ...

    • Acne Treatment Based on Selective Photothermolysis of Sebaceous Follicles with Topically Delivered Light-Absorbing Gold Microparticles 

      Paithankar, Dilip Y; Sakamoto, Fernanda H; Farinelli, William A; Kositratna, Garuna; Blomgren, Richard D; Meyer, Todd J; Faupel, Linda J; Kauvar, Arielle N B; Lloyd, Jenifer R; Cheung, Wang L; Owczarek, Witold D; Suwalska, Anna M; Kochanska, Katarzyna B; Nawrocka, Agnieszka K; Paluchowska, Elwira B; Podolec, Katarzyna M; Pirowska, Magdalena M; Wojas-Pelc, Anna B; Anderson, R Rox (Nature Publishing Group, 2015)
      The pathophysiology of acne vulgaris depends on active sebaceous glands, implying that selective destruction of sebaceous glands could be an effective treatment. We hypothesized that light-absorbing microparticles could ...

    • An acoustic gap between the NICU and womb: a potential risk for compromised neuroplasticity of the auditory system in preterm infants 

      Lahav, Amir; Skoe, Erika (Frontiers Media S.A., 2014)
      The intrauterine environment allows the fetus to begin hearing low-frequency sounds in a protected fashion, ensuring initial optimal development of the peripheral and central auditory system. However, the auditory nursery ...

    • Acoustic Purification of Extracellular Microvesicles 

      Lee, Kyungheon; Shao, Huilin; Weissleder, Ralph; Lee, Hakho (American Chemical Society, 2015)
      Microvesicles (MVs) are an increasingly important source for biomarker discovery and clinical diagnostics. The small size of MVs and their presence in complex biological environment, however, pose technical challenges in ...

    • Acquired acrodermatitis enteropathica after gastric bypass surgery responsive to IV supplementation 

      Rana, Jasmine Kaur; Plovanich, Molly Elizabeth; Wallace, Elizabeth B; Yang, Chao Hui; Canales, Alvaro Laga; Mostaghimi, Arash (University of California, Davis, 2016)
      Nutritional deficiency is rare in developed countries, but can be acquired from decreased nutrient intake, reduced absorption, and increased gastrointestinal excretion. We report a patient with acquired acrodermatitis ...

    • Acquired and Transmitted Multidrug Resistant Tuberculosis: The Role of Social Determinants 

      Odone, Anna; Calderon, Roger; Becerra, Mercedes C.; Zhang, Zibiao; Contreras, Carmen C.; Yataco, Rosa; Galea, Jerome; Lecca, Leonid; Bonds, Matthew H.; Mitnick, Carole D.; Murray, Megan B. (Public Library of Science, 2016)
      Although risk factors for multi-drug resistant tuberculosis are known, few studies have differentiated between acquired and transmitted resistance. It is important to identify factors associated with these different ...