Browsing HMS Scholarly Articles by Title

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    • Ecstasy Exposure & Gender: Examining Components of Verbal Memory Functioning 

      Price, Jenessa S.; Shear, Paula; Lisdahl, Krista M. (Public Library of Science, 2014)
      Objective: Studies have demonstrated verbal memory deficits associated with past year ecstasy use, although specific underlying components of these deficits are less understood. Further, prior research suggests potential ...

    • Ecto-protein kinases and phosphatases: an emerging field for translational medicine 

      Yalak, Garif; Ehrlich, Yigal H; Olsen, Bjorn R (BioMed Central, 2014)
      Progress in translational research has led to effective new treatments of a large number of diseases. Despite this progress, diseases including cancer and cardiovascular disorders still are at the top in death statistics ...

    • Ectonucleotidases in Müller Glial Cells of the Rodent Retina: Involvement in Inhibition of Osmotic Cell Swelling 

      Iandiev, Ianors; Wurm, Antje; Pannicke, Thomas; Wiedemann, Peter; Reichenbach, Andreas; Robson, Simon Christopher; Zimmermann, Herbert; Bringmann, Andreas (Springer Netherlands, 2007)
      Extracellular nucleotides mediate glia-to-neuron signalling in the retina and are implicated in the volume regulation of retinal glial (Müller) cells under osmotic stress conditions. We investigated the expression and ...

    • edgeRun: an R package for sensitive, functionally relevant differential expression discovery using an unconditional exact test 

      Dimont, Emmanuel; Shi, Jiantao; Kirchner, Rory; Hide, Winston (Oxford University Press, 2015)
      Summary: Next-generation sequencing platforms for measuring digital expression such as RNA-Seq are displacing traditional microarray-based methods in biological experiments. The detection of differentially expressed genes ...

    • Edgetic Perturbation Models of Human Inherited Disorders 

      Simonis, Nicolas; Li, Qian-Ru; Heuze, Fabien; Klitgord, Niels; Tam, Stanley; Venkatesan, Kavitha; Mou, Danny; Swearingen, Venus; Yildirim, Muhammed; Dricot, Amélie; Szeto, David; Lin, Chenwei; Hao, Tong; Fan, Changyu; Milstein, Stuart; Dupuy, Denis; Brasseur, Robert; Zhong, Quan; Charloteaux, Benoit; Yu, Haiyuan; Yan, Han; Hill, David E.; Cusick, Michael; Vidal, Marc (Nature Publishing Group, 2009)
      Cellular functions are mediated through complex systems of macromolecules and metabolites linked through biochemical and physical interactions, represented in interactome models as ‘nodes' and ‘edges', respectively. Better ...

    • Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system 

      Cheong, Taek-Chin; Compagno, Mara; Chiarle, Roberto (Nature Publishing Group, 2016)
      Applications of the CRISPR-Cas9 system to edit the genome have widely expanded to include DNA gene knock-out, deletions, chromosomal rearrangements, RNA editing and genome-wide screenings. Here we show the application of ...

    • Editorial 

      Robson, Simon Christopher; Zimmermann, Herbert (Springer Netherlands, 2006)
      "Make everything as simple as possible, but not simpler’’ - Albert Einstein. Nucleosides and nucleotides are primordial biological molecules derived from glycosylamines (comprising nucleobases and variably phosphorylated ...

    • Editorial on Special Topic: Sirtuins in Metabolism, Aging, and Disease 

      Kazantsev, Aleksey G.; Outeiro, Tiago F. (Frontiers Research Foundation, 2012)

    • Editorial: engineering approaches to study cardiovascular physiology: modeling, estimation, and signal processing 

      Chen, Zhe; Barbieri, Riccardo (Frontiers Media S.A., 2012)

    • EDN1 Lys198Asn is Associated with Diabetic Retinopathy in Type 2 Diabetes 

      Li, Haitao; Louey, Janice W.C.; Choy, Kwong Wai; Chan, Yiu Man; Fung, Nicholas S.K.; Baum, Larry; Chan, Juliana C.N.; Lam, Dennis S.C.; Pang, Chi Pui; Liu, David T. L.; Chan, Wai Man; Fan, Baojian (Molecular Vision, 2008)
      Purpose: We tested the hypothesis that genetic variants in vasoactive and angiogenic factors regulating the retina vasculature contribute to the development of diabetic retinopathy (DR). Methods: A case-control study was ...

    • Education Outcomes in a Duty-Hour Flexibility Trial in Internal Medicine 

      Desai, Sanjay V.; Asch, David A.; Bellini, Lisa M.; Chaiyachati, Krisda H.; Liu, Manqing; Sternberg, Alice L.; Tonascia, James; Yeager, Alyssa M.; Asch, Jeremy M.; Katz, Joel; Basner, Mathias; Bates, David; Bilimoria, Karl Y.; Dinges, David F.; Even-Shoshan, Orit; Shade, David M.; Silber, Jeffrey H.; Small, Dylan S.; Volpp, Kevin G.; Shea, Judy A. (Massachusetts Medical Society, 2018-04-19)
      Background: Concern persists that inflexible duty-hour rules in medical residency programs may adversely affect the training of physicians. Methods: We randomly assigned 63 internal medicine residency programs in the ...

    • Educational disadvantage impairs functional recovery after hospitalization in older persons 

      Chaudhry, Sarwat I.; Friedkin, Rebecca J.; Horwitz, Ralph I.; Inouye, Sharon (Elsevier BV, 2004)
      PURPOSE: To determine whether low educational level is associated with poor functional recovery after hospitalization in older adults. METHODS: We followed 862 patients (374 with low education, defined as <high school) ...

    • Educational outcomes of Helping Babies Breathe training at a community hospital in Honduras 

      Seto, Teresa L.; Tabangin, Meredith E.; Josyula, Srirama; Taylor, Kathryn K.; Vasquez, Juan Carlos; Kamath-Rayne, Beena D. (Bohn Stafleu van Loghum, 2015)
      Objectives: Helping Babies Breathe is an evidence-based curriculum designed to teach basic neonatal resuscitation in low-resource countries. The purpose of this study was to evaluate the acquisition of knowledge and skills ...

    • Educational potential of a virtual patient system for caring for traumatized patients in primary care 

      Ekblad, Solvig; Mollica, Richard F; Fors, Uno; Pantziaras, Ioannis; Lavelle, James (BioMed Central, 2013)
      Background: Virtual Patients (VPs) have been used in undergraduate healthcare education for many years. This project is focused on using VPs for training professionals to care for highly vulnerable patient populations. The ...

    • eduSPIM: Light Sheet Microscopy in the Museum 

      Jahr, Wiebke; Schmid, Benjamin; Weber, Michael; Huisken, Jan (Public Library of Science, 2016)
      Light Sheet Microscopy in the Museum Light sheet microscopy (or selective plane illumination microscopy) is an important imaging technique in the life sciences. At the same time, this technique is also ideally suited for ...

    • EEG complexity as a biomarker for autism spectrum disorder risk 

      Bosl, William; Tierney, Adrienne; Tager-Flusberg, Helen; Nelson, Charles A. (Springer Science + Business Media, 2011)
      Background: Complex neurodevelopmental disorders may be characterized by subtle brain function signatures early in life before behavioral symptoms are apparent. Such endophenotypes may be measurable biomarkers for later ...

    • EEG functional connectivity is partially predicted by underlying white matter connectivity 

      Chu, Catherine Jean; Tanaka, Naoaki; Diaz, J.; Edlow, Brian Lewis; Wu, Ona; Hamalainen, Matti S.; Stufflebeam, Steven Marshall; Cash, Sydney S.; Kramer, M.A. (Elsevier BV, 2015)
      Over the past decade, networks have become a leading model to illustrate both the anatomical relationships (structural networks) and the coupling of dynamic physiology (functional networks) linking separate brain regions. ...

    • EEG spectral coherence data distinguish chronic fatigue syndrome patients from healthy controls and depressed patients-A case control study 

      Duffy, Frank Hopkins; McAnulty, Gloria; McCreary, Michelle C; Cuchural, George J; Komaroff, Anthony L. (Springer Nature, 2011)
      Background: Previous studies suggest central nervous system involvement in chronic fatigue syndrome (CFS), yet there are no established diagnostic criteria. CFS may be difficult to differentiate from clinical depression. ...

    • EF24 inhibits tumor growth and metastasis via suppressing NF-kappaB dependent pathways in human cholangiocarcinoma 

      Yin, Da-long; Liang, Ying-jian; Zheng, Tong-sen; Song, Rui-peng; Wang, Jia-bei; Sun, Bo-shi; Pan, Shang-ha; Qu, Lian-dong; Liu, Jia-ren; Jiang, Hong-chi; Liu, Lian-xin (Nature Publishing Group, 2016)
      A synthetic monoketone analog of curcumin, termed 3, 5-bis (2-flurobenzylidene) piperidin-4-one (EF24), has been reported to inhibit the growth of a variety of cancer cells both in vitro and in vivo. However, whether EF24 ...

    • Efavirenz versus boosted atazanavir-containing regimens and immunologic, virologic, and clinical outcomes: A prospective study of HIV-positive individuals 

      Cain, Lauren E.; Caniglia, Ellen C.; Phillips, Andrew; Olson, Ashley; Muga, Roberto; Pérez-Hoyos, Santiago; Abgrall, Sophie; Costagliola, Dominique; Rubio, Rafael; Jarrín, Inma; Bucher, Heiner; Fehr, Jan; van Sighem, Ard; Reiss, Peter; Dabis, François; Vandenhende, Marie-Anne; Logan, Roger; Robins, James; Sterne, Jonathan A. C.; Justice, Amy; Tate, Janet; Touloumi, Giota; Paparizos, Vasilis; Esteve, Anna; Casabona, Jordi; Seng, Rémonie; Meyer, Laurence; Jose, Sophie; Sabin, Caroline; Hernán, Miguel A. (Wolters Kluwer Health, 2016)
      Abstract Objective: To compare regimens consisting of either ritonavir-boosted atazanavir or efavirenz and a nucleoside reverse transcriptase inhibitor (NRTI) backbone with respect to clinical, immunologic, and virologic ...