Browsing HMS Scholarly Articles by Title

Now showing items 6748-6767 of 17922

    • Genes Involved in Complex Adaptive Processes Tend to Have Highly Conserved Upstream Regions in Mammalian Genomes 

      Lee, Soohyun; Kohane, Isaac Samuel; Kasif, Simon (BioMed Central, 2005)
      Background: Recent advances in genome sequencing suggest a remarkable conservation in gene content of mammalian organisms. The similarity in gene repertoire present in different organisms has increased interest in studying ...

    • Genes Involved in Formation of Structured Multicellular Communities by Bacillus subtilis 

      Branda, Steven S.; González-Pastor, José Eduardo; Dervyn, Etienne; Ehrlich, S. Dusko; Losick, Richard; Kolter, Roberto (American Society for Microbiology, 2004)

    • Genes to Diseases (G2D) Computational Method to Identify Asthma Candidate Genes 

      Tremblay, Karine; Lemire, Mathieu; Potvin, Camille; Tremblay, Alexandre; Hudson, Thomas J.; Perez-Iratxeta, Carolina; Andrade-Navarro, Miguel A.; Laprise, Catherine; Hunninghake, Gary Matthew; Raby, Benjamin Alexander (Public Library of Science, 2008)
      Asthma is a complex trait for which different strategies have been used to identify its environmental and genetic predisposing factors. Here, we describe a novel methodological approach to select candidate genes for asthma ...

    • Genes with monoallelic expression contribute disproportionately to genetic diversity in humans 

      Savova, Virginia; Chun, Sung; Sohail, Mashaal; McCole, Ruth B.; Witwicki, Robert; Gai, Lisa; Lenz, Tobias L.; Wu, C.-ting; Sunyaev, Shamil R.; Gimelbrant, Alexander A. (2016)
      An unexpectedly large number of human autosomal genes are subject to monoallelic expression (MAE). Our analysis of 4,227 such genes reveals surprisingly high genetic variation across human populations. This increased ...

    • Genesis and growth of extracellular vesicle-derived microcalcification in atherosclerotic plaques 

      Hutcheson, Joshua D.; Goettsch, Claudia; Bertazzo, Sergio; Maldonado, Natalia; Ruiz, Jessica L.; Goh, Wilson; Yabusaki, Katsumi; Faits, Tyler; Bouten, Carlijn; Franck, Gregory; Quillard, Thibaut; Libby, Peter; Aikawa, Masanori; Weinbaum, Sheldon; Aikawa, Elena (2015)
      Clinical evidence links arterial calcification and cardiovascular risk. Finite-element modelling of the stress distribution within atherosclerotic plaques has suggested that subcellular microcalcifications in the fibrous ...

    • Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells 

      Odorizzi, Pamela M.; Pauken, Kristen E.; Paley, Michael A.; Sharpe, Arlene; Wherry, E. John (The Rockefeller University Press, 2015)
      Programmed Death-1 (PD-1) has received considerable attention as a key regulator of CD8+ T cell exhaustion during chronic infection and cancer because blockade of this pathway partially reverses T cell dysfunction. Although ...

    • Genetic Analyses of Conserved Residues in the Carboxyl-Terminal Domain of Human Immunodeficiency Virus Type 1 Integrase 

      Lu, Richard; Ghory, Hina Z.; Engelman, Alan (American Society for Microbiology, 2005)
      Results of in vitro assays identified residues in the C-terminal domain (CTD) of human immunodeficiency virus type 1 (HIV-1) integrase (IN) important for IN-IN and IN-DNA interactions, but the potential roles of these ...

    • Genetic Analyses of DNA-Binding Mutants in the Catalytic Core Domain of Human Immunodeficiency Virus Type 1 Integrase 

      Lu, Richard; Limón, Ana; Ghory, Hina Z.; Engelman, Alan (American Society for Microbiology, 2005)
      The catalytic core domain (CCD) of human immunodeficiency virus type 1 (HIV-1) integrase (IN) harbors the enzyme active site and binds viral and chromosomal DNA during integration. Thirty-five CCD mutant viruses were ...

    • Genetic Analysis of Activation of the Vibrio cholerae Cpx Pathway 

      Slamti, Leyla; Waldor, Matthew K. (American Society for Microbiology, 2009)
      The Cpx two-component system is thought to mediate envelope stress responses in many gram-negative bacteria and has been implicated in the pathogenicity of several enteric pathogens. While cues that activate the Escherichia ...

    • Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers 

      Shen, Li; Thompson, Paul M.; Potkin, Steven G.; Bertram, Lars; Farrer, Lindsay A.; Foroud, Tatiana M.; Green, Robert C.; Hu, Xiaolan; Huentelman, Matthew J.; Kim, Sungeun; Kauwe, John S. K.; Li, Qingqin; Liu, Enchi; Macciardi, Fabio; Moore, Jason H.; Munsie, Leanne; Nho, Kwangsik; Ramanan, Vijay K.; Risacher, Shannon L.; Stone, David J.; Swaminathan, Shanker; Toga, Arthur W.; Weiner, Michael W.; Saykin, Andrew J. (Springer US, 2013)
      The Genetics Core of the Alzheimer’s Disease Neuroimaging Initiative (ADNI), formally established in 2009, aims to provide resources and facilitate research related to genetic predictors of multidimensional Alzheimer’s ...

    • Genetic Analysis of the Roles of BMP2, BMP4, and BMP7 in Limb Patterning and Skeletogenesis 

      Bandyopadhyay, Amitabha; Tsuji, Kunikazu; Cox, Karen Ann; Harfe, Brian D; Rosen, Vicki; Tabin, Clifford James (Public Library of Science, 2006)
      Bone morphogenetic protein (BMP) family members, including BMP2, BMP4, and BMP7, are expressed throughout limb development. BMPs have been implicated in early limb patterning as well as in the process of skeletogenesis. ...

    • Genetic analysis of Vibrio parahaemolyticus intestinal colonization 

      Hubbard, Troy; Chao, Michael; Sören Abel; Blondel, Carlos; Pia Abel zur Wiesch; Zhou, Xiaohui; Davis, Brigid; Waldor, Matthew (National Academy of Sciences, 2016)
      Vibrio parahaemolyticus is the most common cause of seafood-borne gastroenteritis worldwide and a blight on global aquaculture. This organism requires a horizontally acquired type III secretion system (T3SS2) to infect the ...

    • Genetic and Clinical Risk Prediction Model for Postoperative Atrial Fibrillation 

      Kolek, M. J.; Muehlschlegel, Jochen Daniel; Bush, W. S.; Parvez, B.; Murray, K. T.; Stein, C. M.; Shoemaker, M. B.; Blair, M. A.; Kor, K. C.; Roden, D. M.; Donahue, B. S.; Fox, A. A.; Shernan, S. K.; Collard, C. D.; Body, Simon Christopher; Darbar, D. (Ovid Technologies (Wolters Kluwer Health), 2015)
      Background—Postoperative atrial fibrillation (PoAF) is common after coronary artery bypass grafting. We previously showed that atrial fibrillation susceptibility single nucleotide polymorphisms (SNPs) at the chromosome ...

    • A genetic and computational approach to structurally classify neuronal types 

      Sümbül, Uygar; Song, Sen; McCulloch, Kyle; Becker, Michael; Lin, Bin; Sanes, Joshua R.; Masland, Richard H.; Seung, H. Sebastian (2014)
      The importance of cell types in understanding brain function is widely appreciated but only a tiny fraction of neuronal diversity has been catalogued. Here, we exploit recent progress in genetic definition of cell types ...

    • Genetic and Epigenetic Fine-Mapping of Causal Autoimmune Disease Variants 

      Farh, Kyle Kai-How; Marson, Alexander; Zhu, Jiang; Kleinewietfeld, Markus; Housley, William J.; Beik, Samantha; Shoresh, Noam; Whitton, Holly; Ryan, Russell J.H.; Shishkin, Alexander A.; Hatan, Meital; Carrasco-Alfonso, Marlene J.; Mayer, Dita; Luckey, C. John; Patsopoulos, Nikolaos A.; De Jager, Philip L.; Kuchroo, Vijay K.; Epstein, Charles B; Daly, Mark J.; Hafler, David A.; Bernstein, Bradley E. (2014)
      Summary Genome-wide association studies have identified loci underlying human diseases, but the causal nucleotide changes and mechanisms remain largely unknown. Here we developed a fine-mapping algorithm to identify candidate ...

    • Genetic and functional analyses implicate the NUDT11, HNF1B, and SLC22A3 genes in prostate cancer pathogenesis 

      Grisanzio, Chiara; Werner, Lillian; Takeda, David; Awoyemi, Bisola C.; Pomerantz, Mark M.; Yamada, Hiroki; Sooriakumaran, Prasanna; Robinson, Brian D.; Leung, Robert; Schinzel, Anna C.; Mills, Ian; Ross-Adams, Helen; Neal, David E.; Kido, Masahito; Yamamoto, Toshihiro; Petrozziello, Gillian; Stack, Edward C.; Lis, Rosina; Kantoff, Philip W.; Loda, Massimo; Sartor, Oliver; Egawa, Shin; Tewari, Ashutosh K.; Hahn, William C.; Freedman, Matthew L. (National Academy of Sciences, 2012)
      One of the central goals of human genetics is to discover the genes and pathways driving human traits. To date, most of the common risk alleles discovered through genome-wide association studies (GWAS) map to nonprotein-coding ...

    • A Genetic and Functional Relationship between T Cells and Cellular Proliferation in the Adult Hippocampus 

      Huang, Guo-Jen; Smith, Adrian L.; Gray, Daniel H.D.; Cosgrove, Cormac; Singer, Benjamin H.; Edwards, Andrew; Sim, Stuart; Parent, Jack M.; Johnsen, Alyssa; Mott, Richard; Klenerman, Paul; Flint, Jonathan; Mathis, Diane J.; Benoist, Christophe O. (Public Library of Science, 2010)
      Neurogenesis continues through the adult life of mice in the subgranular zone of the dentate gyrus in the hippocampus, but its function remains unclear. Measuring cellular proliferation in the hippocampus of 719 outbred ...

    • Genetic and Functional Studies Implicate Synaptic Overgrowth and Ring Gland cAMP/PKA Signaling Defects in the Drosophila melanogaster Neurofibromatosis-1 Growth Deficiency 

      Walker, James A.; Gouzi, Jean Y.; Long, Jennifer B.; Huang, Sidong; Maher, Robert C.; Xia, Hongjing; Khalil, Kheyal; Ray, Arjun; Van Vactor, David; Bernards, René; Bernards, André (Public Library of Science, 2013)
      Neurofibromatosis type 1 (NF1), a genetic disease that affects 1 in 3,000, is caused by loss of a large evolutionary conserved protein that serves as a GTPase Activating Protein (GAP) for Ras. Among Drosophila melanogaster ...

    • Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron–sulfur deficiency and pulmonary hypertension 

      White, Kevin; Lu, Yu; Annis, Sofia; Hale, Andrew E; Chau, B Nelson; Dahlman, James E; Hemann, Craig; Opotowsky, Alexander R; Vargas, Sara O; Rosas, Ivan; Perrella, Mark A; Osorio, Juan C; Haley, Kathleen J; Graham, Brian B; Kumar, Rahul; Saggar, Rajan; Saggar, Rajeev; Wallace, W Dean; Ross, David J; Khan, Omar F; Bader, Andrew; Gochuico, Bernadette R; Matar, Majed; Polach, Kevin; Johannessen, Nicolai M; Prosser, Haydn M; Anderson, Daniel G; Langer, Robert; Zweier, Jay L; Bindoff, Laurence A; Systrom, David; Waxman, Aaron B; Jin, Richard C; Chan, Stephen Y (BlackWell Publishing Ltd, 2015)
      Iron–sulfur (Fe-S) clusters are essential for mitochondrial metabolism, but their regulation in pulmonary hypertension (PH) remains enigmatic. We demonstrate that alterations of the miR-210-ISCU1/2 axis cause Fe-S deficiencies ...

    • Genetic and Pharmacological Modifications of Thrombin Formation in Apolipoprotein E-deficient Mice Determine Atherosclerosis Severity and Atherothrombosis Onset in a Neutrophil-Dependent Manner 

      Borissoff, Julian I; Otten, Jeroen J. T.; Heeneman, Sylvia; Leenders, Peter; van Oerle, René; Soehnlein, Oliver; Loubele, Sarah T. B. G.; Hamulyák, Karly; Hackeng, Tilman M.; Daemen, Mat J. A. P.; Degen, Jay L.; Weiler, Hartmut; Esmon, Charles T.; van Ryn, Joanne; Biessen, Erik A. L.; Spronk, Henri M. H.; ten Cate, Hugo (Public Library of Science, 2013)
      Background: Variations in the blood coagulation activity, determined genetically or by medication, may alter atherosclerotic plaque progression, by influencing pleiotropic effects of coagulation proteases. Published ...