dc.contributor.author | Corey, Kathleen Elizabeth | |
dc.contributor.author | Zheng, Zheng | |
dc.contributor.author | Mendez-Navarro, Jorge | |
dc.contributor.author | Delgado-Borrego, Aymin | |
dc.contributor.author | Dienstag, Jules Leonard | |
dc.contributor.author | Chung, Raymond Taeyong | |
dc.date.accessioned | 2012-08-03T11:59:16Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Corey, Kathleen E., Hui Zheng, Jorge Mendez-Navarro, Aymin Delgado-Borrego, Jules L. Dienstag, and Raymond T. Chung. 2012. Serum vitamin D levels are not predictive of the progression of chronic liver disease in Hepatitis C patients with advanced fibrosis. PLoS ONE 7(2): e27144. | en_US |
dc.identifier.issn | 1932-6203 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:9361514 | |
dc.description.abstract | In animal models and human cross-sectional studies, vitamin D deficiency has been associated with liver disease progression. Vitamin D supplementation has been suggested as a treatment to prevent disease progression. We sought to evaluate the role of vitamin D levels in predicting chronic liver disease development. We conducted a nested case-control study of vitamin D levels in subjects with (cases) and without (controls) liver histologic progression or clinical decompensation over the course of the HALT-C Trial. Vitamin D levels were measured at 4 points over 45 months. 129 cases and 129 aged-matched controls were included. No difference in baseline vitamin D levels were found between cases and controls. (44.8 ng/mL vs. 44.0 ng/mL, P = 0.74). Vitamin D levels declined in cases and controls over time (P = 0.0005), however, there was no difference in the level of decline (P = 0.37). Among study subjects with diabetes mellitius, baseline vitamin D levels were higher in cases, 49.9 ng/mL, than controls, 36.3 ng/mL. (P = 0.03) In addition, baseline vitamin D levels were higher in black case subjects, 32.7 ng/mL, than in black control subjects, 25.2 ng/mL (P = 0.08) No difference in vitamin D levels was found between patients with and without progression of hepatitis C-associated liver disease over 4 years. Our data do not suggest any role for vitamin D supplementation in patients with advanced chronic hepatitis C and raise the possibility that higher vitamin D levels may be associated with disease progression. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Public Library of Science | en_US |
dc.relation.isversionof | doi:10.1371/journal.pone.0027144 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281016/pdf/ | en_US |
dash.license | LAA | |
dc.subject | medicine | en_US |
dc.subject | gastroenterology and hepatology | en_US |
dc.subject | liver diseases | en_US |
dc.subject | infectious hepatitis | en_US |
dc.title | Serum Vitamin D Levels are not Predictive of the Progression of Chronic Liver Disease in Hepatitis C Patients with Advanced Fibrosis | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | PLoS ONE | en_US |
dash.depositing.author | Corey, Kathleen Elizabeth | |
dc.date.available | 2012-08-03T11:59:16Z | |
dc.identifier.doi | 10.1371/journal.pone.0027144 | * |
dash.contributor.affiliated | Dienstag, Jules | |
dash.contributor.affiliated | Corey, Kathleen | |
dash.contributor.affiliated | Zheng, Hui | |
dash.contributor.affiliated | Chung, Raymond | |