Browsing by Author "Hooker, Jacob"
Now showing items 41-54 of 54
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Radiosynthesis and Evaluation of [11C]EMPA as a Potential PET Tracer for Orexin 2 Receptors
Wang, Changning; Moseley, Christian K.; Carlin, Stephen M.; Wilson, Colin M.; Neelamegam, Ramesh; Hooker, Jacob M (Elsevier BV, 2013)EMPA is a selective antagonist of orexin 2 (OX2) receptors. Previous literature with [3H]-EMPA suggest that it may be used as an imaging agent for OX2 receptors; however, brain penetration is known to be modest. To evaluate ... -
Radiosynthesis of C-11 Labeled Auxin (3-Indolyl[1-11C]acetic Acid) and Its Derivatives from Gramine
Reid, Alicia E.; Kim, Sung Won; Seiner, Brienne; Fowler, Frank W.; Hooker, Jacob M; Ferrieri, Richard; Babst, Benjamin; Fowler, Joanna S. (Wiley-Blackwell, 2011)3-Indolylacetic acid (IAA) is the major auxin in higher plants and plays a key role in plant growth and development. We report the rapid radiolabeling of the important plant hormone using carbon-11 (half life: 20.4 min) ... -
Rapid Chemoselective Bioconjugation Through Oxidative Coupling of Anilines and Aminophenols
Behrens, Christopher R.; Hooker, Jacob M; Obermeyer, Allie C.; Romanini, Dante W.; Katz, Elan M.; Francis, Matthew B. (American Chemical Society (ACS), 2011)A highly efficient protein bioconjugation method is described involving addition of anilines to o-aminophenols in the presence of sodium periodate. The reaction takes place in aqueous buffer at pH 6.5 and can reach high ... -
A Receptor-Based Model for Dopamine-Induced fMRI Signal
Mandeville, Joseph B.; Sander, Christin Y.M.; Jenkins, Bruce Gorton; Hooker, Jacob M; Catana, Ciprian; Vanduffel, Wim J.M.; Alpert, Nathaniel Moritz; Rosen, Bruce; Normandin, Marc D (Elsevier BV, 2013)This report describes a multi-receptor physiological model of the fMRI temporal response and signal magnitude evoked by drugs that elevate synaptic dopamine in basal ganglia. The model is formulated as a summation of ... -
Reinvestigation of the Synthesis and Evaluation of [N-methyl-11C]vorozole, a Radiotracer Targeting Cytochrome P450 Aromatase
Kim, Sung Won; Biegon, Anat; Katsamanis, Zachary E.; Ehrlich, Carolin W.; Hooker, Jacob M; Shea, Colleen; Muench, Lisa; Xu, Youwen; King, Payton; Carter, Pauline; Alexoff, David L.; Fowler, Joanna S. (Elsevier BV, 2009)Introduction: We reinvestigated the synthesis of [N-methyl-11C]vorozole, a radiotracer for aromatase, and discovered the presence of an N-methyl isomer which was not removed in the original purification method. Herein we ... -
Salvinorin A and Derivatives: Protection from Metabolism Does Not Prolong Short-Term, Whole-Brain Residence
Hooker, Jacob M; Munro, Thomas A.; Béguin, Cécile; Alexoff, David; Shea, Colleen; Xu, Youwen; Cohen, Bruce M. (Elsevier BV, 2009)Salvinorin A (SA) is a potent kappa opioid agonist with a brief duration of action. Consistent with this, our previous positron emission tomography (PET) studies of carbon-11 labeled SA showed that brain levels decrease ... -
A Selective HDAC 1/2 Inhibitor Modulates Chromatin and Gene Expression in Brain and Alters Mouse Behavior in Two Mood-Related Tests
Schroeder, Frederick A.; Lewis, Michael C.; Fass, Daniel M.; Wagner, Florence F.; Zhang, Yan-Ling; Hennig, Krista M.; Gale, Jennifer; Zhao, Wen-Ning; Reis, Surya; Barker, Douglas D.; Berry-Scott, Erin; Kim, Sung Won; Clore, Elizabeth L.; Hooker, Jacob M.; Holson, Edward B.; Haggarty, Stephen J.; Petryshen, Tracey L. (Public Library of Science, 2013)Psychiatric diseases, including schizophrenia, bipolar disorder and major depression, are projected to lead global disease burden within the next decade. Pharmacotherapy, the primary – albeit often ineffective – treatment ... -
A Simple, Rapid Method for the Preparation of [11 C]Formaldehyde
Hooker, Jacob M; Schönberger, Matthias; Schieferstein, Hanno; Fowler, Joanna S. (Wiley-Blackwell, 2008)A PET project: A powerful reagent for the synthesis of positron-emitting imaging molecules—[11C]formaldehyde—is accessible from [11C]methyl iodide and trimethylamine N-oxide (TMAO) in high yields and under mild conditions. ... -
Synthesis and Evaluation of Methylated Arylazepine Compounds for PET Imaging of 5-HT 2c Receptors
Granda, Michael L.; Carlin, Stephen M.; Moseley, Christian K.; Neelamegam, Ramesh; Mandeville, Joseph B.; Hooker, Jacob M (American Chemical Society (ACS), 2013)The serotonin 5-HT2c receptor is implicated in a number of diseases including obesity, depression, anxiety, and schizophrenia. In order to ascribe the role of 5-HT2c in these diseases, a method for measuring 5-HT2c density ... -
Synthesis of [ 11 C]Bexarotene by Cu-Mediated [ 11 C]Carbon Dioxide Fixation and Preliminary PET Imaging
Rotstein, Benjamin H; Hooker, Jacob M; Woo, Jiyeon; Collier, Thomas L; Brady, Thomas Joseph; Liang, Steven; Vasdev, Neil (American Chemical Society (ACS), 2014) -
Synthesis of [\(^{11}\)C]SSR149415 and Preliminary Imaging Studies Using Positron Emission Tomography
Schönberger, Matthias; Leggett, Carmine; Kim, Sung Won; Hooker, Jacob M (Elsevier BV, 2010)SSR149415 was the first non-peptide vasopressin-(V\(_{1b}\)) receptor antagonist reported. It has been used to probe the role of V\(_{1b}\) receptors in animal models of depression, aggression, and stress-anxiety, and was ... -
A Transmetalation Reaction Enables the Synthesis of [18F]5-Fluorouracil from [18F]Fluoride for Human PET Imaging
Hoover, Andrew J.; Lazari, Mark; Ren, Hong; Narayanam, Maruthi Kumar; Murphy, Jennifer M.; van Dam, R. Michael; Hooker, Jacob M.; Ritter, Tobias (American Chemical Society, 2016)Translation of new 18F-fluorination reactions to produce radiotracers for human positron emission tomography (PET) imaging is rare because the chemistry must have useful scope and the process for 18F-labeled tracer production ... -
Visualizing Epigenetics: Current Advances and Advantages in HDAC PET Imaging Techniques
Wang, Changning; Schroeder, Frederick A; Hooker, Jacob M (Elsevier BV, 2014)Abnormal gene regulation as a consequence of flawed epigenetic mechanisms may be central to the initiation and persistence of many human diseases. However, the association of epigenetic dysfunction with disease and the ... -
Whole-Body Pharmacokinetics of HDAC Inhibitor Drugs, Butyric Acid, Valproic Acid and 4-Phenylbutyric Acid Measured with Carbon-11 Labeled Analogs by PET
Kim, Sung Won; Hooker, Jacob M; Otto, Nicola; Win, Khaing; Muench, Lisa; Shea, Colleen; Carter, Pauline; King, Payton; Reid, Alicia E.; Volkow, Nora D.; Fowler, Joanna S. (Elsevier BV, 2013)The fatty acids, n-butyric acid (BA), 4-phenylbutyric acid (PBA) and valproic acid (VPA, 2-propylpentanoic acid) have been used for many years in the treatment of a variety of CNS and peripheral organ diseases including ...