Browsing by Author "Pukkila-Worley, Read"

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    • The Evolutionarily Conserved Mediator Subunit MDT-15/MED15 Links Protective Innate Immune Responses and Xenobiotic Detoxification 

      Pukkila-Worley, Read; Feinbaum, Rhonda L.; McEwan, Deborah L.; Conery, Annie L.; Ausubel, Frederick M. (Public Library of Science, 2014)
      Metazoans protect themselves from environmental toxins and virulent pathogens through detoxification and immune responses. We previously identified a small molecule xenobiotic toxin that extends survival of Caenorhabditis ...

    • Evolutionarily Conserved Recognition and Innate Immunity to Fungal Pathogens by the Scavenger Receptors SCARF1 and CD36 

      Tampakakis, Emmanouil; Puckett, Lindsay; Tai, Melissa F.; Stewart, Cameron R.; Hickman, Suzanne E.; Moore, Kathryn J.; El Khoury, Joseph; Means, Terry K.; Mylonakis, Eleftherios; Colvin, Richard Anthony; Seung, Edward N.; Pukkila-Worley, Read; Calderwood, Stephen Beaven; Hacohen, Nir; Luster, Andrew David (Rockefeller University Press, 2009)
      Receptors involved in innate immunity to fungal pathogens have not been fully elucidated. We show that the Caenorhabditis elegans receptors CED-1 and C03F11.3, and their mammalian orthologues, the scavenger receptors SCARF1 ...

    • The Role of Candida albicans SPT20 in Filamentation, Biofilm Formation and Pathogenesis 

      Tan, Xiaojiang; Fuchs, Beth Burgwyn; Wang, Yan; Chen, Weiping; J. Yuen, Grace; Chen, Rosalyn B.; Jayamani, Elamparithi; Anastassopoulou, Cleo; Pukkila-Worley, Read; Coleman, Jeffrey J.; Mylonakis, Eleftherios (Public Library of Science, 2014)
      Candida albicans is a ubiquitous fungus, which can cause very serious and sometimes life-threatening infections in susceptible patients. We used Caenorhabditis elegans as a model host to screen a library of C. albicans ...

    • Stimulation of Host Immune Defenses by a Small Molecule Protects C. elegans from Bacterial Infection 

      Pukkila-Worley, Read; Feinbaum, Rhonda Lorin; Kirienko, Natalia; Larkins-Ford, Jonah; Conery, Annie L.; Ausubel, Frederick M. (Public Library of Science, 2012)
      The nematode Caenorhabditis elegans offers currently untapped potential for carrying out high-throughput, live-animal screens of low molecular weight compound libraries to identify molecules that target a variety of cellular ...