Browsing by Author "Levitsky, Sidney"

Now showing items 1-13 of 13

    • Actin-dependent mitochondrial internalization in cardiomyocytes: evidence for rescue of mitochondrial function 

      Pacak, Christina A.; Preble, Janine M.; Kondo, Hiroshi; Seibel, Peter; Levitsky, Sidney; del Nido, Pedro J.; Cowan, Douglas B.; McCully, James D. (The Company of Biologists, 2015)
      Previously, we have demonstrated that the transplantation of viable, structurally intact, respiration competent mitochondria into the ischemic myocardium during early reperfusion significantly enhanced cardioprotection by ...

    • Age- and Gender-Related Differences in Ischemia/Reperfusion Injury and Cardioprotection: Effects of Diazoxide 

      McCully, James Donald; Toyoda, Yoshiya; Wakiyama, Hidetaka; Rousou, Anthony J.; Parker, Robert A; Levitsky, Sidney (Elsevier BV, 2006)
      Background Recent studies have demonstrated that aging is associated with reduced tolerance to ischemia and that the aged (not senescent) female heart has greater susceptibility to ischemia as compared with the aged ...

    • Age- and Gender-Related Differences in Mitochondrial Oxygen Consumption and Calcium With Cardioplegia and Diazoxide 

      McCully, James Donald; Rousou, Anthony J.; Parker, Robert A; Levitsky, Sidney (Elsevier BV, 2007)
      Background We have recently shown that the cardioprotection afforded by cardioplegia is affected by age and gender and is less effective in the aged female rabbit heart compared with the aged male rabbit heart. We ...

    • Cardioplegia and Diazoxide Modulate STAT3 Activation and DNA Binding 

      Hsieh, Yng-Ju; Wakiyama, Hidetaka; Levitsky, Sidney; McCully, James Donald (Elsevier BV, 2007)
      Background Previously, we have shown that magnesium supplemented potassium (DSA) cardioplegia and DSA containing diazoxide (DSA+DZX) significantly decrease apoptosis after ischemia. The mechanism for this enhanced ...

    • Derivation and Validation of a Preoperative Prediction Rule for Delirium After Cardiac Surgery 

      Rudolph, James; Jones, Richard Norman; Levkoff, Sue E.; Rockett, C.; Inouye, Sharon; Sellke, F. W.; Khuri, S. F.; Lipsitz, Lewis Arnold; Ramlawi, B.; Levitsky, Sidney; Marcantonio, Edward Ralph (Ovid Technologies (Wolters Kluwer Health), 2008)
      Background— Delirium is a common outcome after cardiac surgery. Delirium prediction rules identify patients at risk for delirium who may benefit from targeted prevention strategies, early identification, and treatment of ...

    • Diazoxide amelioration of myocardial injury and mitochondrial damage during cardiac surgery 

      McCully, James Donald; Wakiyama, Hidetaka; Cowan, Douglas Burr; Federman, Micheline; Parker, Robert A; Levitsky, Sidney (Elsevier BV, 2002)
      Background Recently, we have shown that the selective opening of mitochondrial ATP-sensitive potassium channels with diazoxide significantly decreases myocardial injury. The purpose of this study was to determine the ...

    • Differential Expression of Collagen Type V and XI ?-1 in Human Ascending Thoracic Aortic Aneurysms 

      Toumpoulis, Ioannis K.; Oxford, Julia Thom; Cowan, Douglas Burr; Anagnostopoulos, Constantine E.; Rokkas, Chris K.; Chamogeorgakis, Themistocles P.; Angouras, Dimitrios C.; Shemin, Richard J.; Navab, Mohamad; Ericsson, Maria; Federman, Micheline; Levitsky, Sidney; McCully, James Donald (Elsevier BV, 2009)
      Background The molecular mechanisms leading to ascending thoracic aortic aneurysms (ATAAs) remain unknown. We hypothesized that alterations in expression levels of specific fibrillar collagens occur during the aneurysmal ...

    • Effect of type of dietary fat and ethanol on antioxidant enzyme mRNA induction in rat liver. 

      Nanji, A. A.; Griniuviene, B.; Sadrzadeh, S. M.; Levitsky, Sidney; McCully, James Donald (American Society for Biochemistry and Molecular Biology, 1995)
      We carried out a study to relate the effect of the type of dietary fat and ethanol on antioxidant enzyme mRNA levels in liver in the intragastric feeding rat model. Different types of dietary fat were administered [saturated ...

    • Intracoronary Delivery of Mitochondria to the Ischemic Heart for Cardioprotection 

      Cowan, Douglas B.; Yao, Rouan; Akurathi, Vamsidhar; Snay, Erin R.; Thedsanamoorthy, Jerusha K.; Zurakowski, David; Ericsson, Maria; Friehs, Ingeborg; Wu, Yaotang; Levitsky, Sidney; del Nido, Pedro J.; Packard, Alan B.; McCully, James D. (Public Library of Science, 2016)
      We have previously shown that transplantation of autologously derived, respiration-competent mitochondria by direct injection into the heart following transient ischemia and reperfusion enhances cell viability and contractile ...

    • Mitochondrial transplantation for therapeutic use 

      McCully, James Donald; Levitsky, Sidney; Del Nido, Pedro J.; Cowan, Douglas Burr (Springer Science + Business Media, 2016)
      Mitochondria play a key role in the homeostasis of the vast majority of the body’s cells. In the myocardium where mitochondria constitute 30 % of the total myocardial cell volume, temporary attenuation or obstruction of ...

    • Preliminary Biomarkers for Identification of Human Ascending Thoracic Aortic Aneurysm 

      Black, Kendra M.; Masuzawa, Akihiro; Hagberg, Robert C.; Khabbaz, Kamal R.; Trovato, Mary E.; Rettagliati, Verna M.; Bhasin, Manoj K.; Dillon, Simon T.; Libermann, Towia A.; Toumpoulis, Ioannis K.; Levitsky, Sidney; McCully, James D. (Blackwell Publishing Ltd, 2013)
      Background: Human ascending thoracic aortic aneurysms (ATAAs) are life threatening and constitute a leading cause of mortality in the United States. Previously, we demonstrated that collagens α2(V) and α1(XI) mRNA and ...

    • Reduction and Redistribution of Gap and Adherens Junction Proteins After Ischemia and Reperfusion 

      Tansey, Erin E.; Kwaku, Kevin F.; Hammer, Peter; Cowan, Douglas Burr; Federman, Micheline; Levitsky, Sidney; McCully, James Donald (Elsevier BV, 2006)
      Background Previous studies have demonstrated that alterations in myocardial structure, consistent with tissue and sarcomere disruption as well as myofibril dissociation, occur after myocardial ischemia and reperfusion. ...

    • Selective opening of mitochondrial ATP-sensitive potassium channels during surgically induced myocardial ischemia decreases necrosis and apoptosis 

      Wakiyama, H; Cowan, Douglas Burr; Toyoda, Yoshiya; Federman, Miceline; Levitsky, Sidney; McCully, James Donald (Oxford University Press (OUP), 2002)
      Objective: Mitochondrial ATP-sensitive potassium channels have been proposed to be myoprotective. The relevance and specificity of this mechanism in cardiac surgery was unknown. The purpose of this study was to examine the ...