Browsing by Author "Josephson, Lee"
Now showing items 1-7 of 7
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Effects of ferumoxytol on quantitative PET measurements in simultaneous PET/MR whole-body imaging: a pilot study in a baboon model
Borra, Ronald JH; Cho, Hoon-Sung; Bowen, Spencer L; Attenberger, Ulrike; Arabasz, Grae; Catana, Ciprian; Josephson, Lee; Rosen, Bruce R; Guimaraes, Alexander R; Hooker, Jacob M (Springer International Publishing, 2015)Background: Simultaneous PET/MR imaging depends on MR-derived attenuation maps (mu-maps) for accurate attenuation correction of PET data. Currently, these maps are derived from gradient-echo-based MR sequences, which are ... -
Magnetic Nanoparticle Sensors
Koh, Isaac; Josephson, Lee (Molecular Diversity Preservation International (MDPI), 2009)Many types of biosensors employ magnetic nanoparticles (diameter = 5–300 nm) or magnetic particles (diameter = 300–5,000 nm) which have been surface functionalized to recognize specific molecular targets. Here we cover ... -
PEG-Like Nanoprobes: Multimodal, Pharmacokinetically and Optically Tunable Nanomaterials
Guo, Yanyan; Yuan, Hushan; Claudio, Natalie M.; Kura, Sreekanth; Shakerdge, Naomi; Mempel, Thorsten R.; Bacskai, Brian J.; Josephson, Lee (Public Library of Science, 2014)“PEG-like Nanoprobes” (PN’s) are pharmacokinetically and optically tunable nanomaterials whose disposition in biological systems can be determined by fluorescence or radioactivity. PN’s feature a unique design where a ... -
Quantitative Analysis of Chemotherapeutic Effects in Tumors Using In Vivo Staining and Correlative Histology
Choi, Heung Kook; Yessayan, Doreen; Choi, Hyun Ju; Schellenberger, Eyk; Bogdanov, Alex; Josephson, Lee; Weissleder, Ralph; Ntziachristos, Vasilis (IOS Press, 2005)Aims: To microscopically analyze the chemotherapeutic response of tumors using in vivo staining based on an annexinV-Cy5.5 probe and independently asses their apoptotic count using quantitative histological analysis. ... -
Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and Survival
Chen, Howard H.; Yuan, Hushan; Josephson, Lee; Sosnovik, David E. (Ivyspring International Publisher, 2012)Several signaling cascades are involved in cell death, with a significant amount of crosstalk between them. Despite the complexity of these cascades several key pro-survival and pro-death players have been identified. These ... -
U-SPECT-BioFluo: an integrated radionuclide, bioluminescence, and fluorescence imaging platform
van Oosterom, Matthias N; Kreuger, Rob; Buckle, Tessa; Mahn, Wendy A; Bunschoten, Anton; Josephson, Lee; van Leeuwen, Fijs WB; Beekman, Freek J (Springer, 2014)Background: In vivo bioluminescence, fluorescence, and single-photon emission computed tomography (SPECT) imaging provide complementary information about biological processes. However, to date these signatures are evaluated ... -
Use of a Single Hybrid Imaging Agent for Integration of Target Validation with In Vivo and Ex Vivo Imaging of Mouse Tumor Lesions Resembling Human DCIS
Buckle, Tessa; Kuil, Joeri; van den Berg, Nynke S.; Bunschoten, Anton; Lamb, Hildo J.; Yuan, Hushan; Josephson, Lee; Jonkers, Jos; Borowsky, Alexander D.; van Leeuwen, Fijs W. B. (Public Library of Science, 2013)Screening of biomarker expression levels in tumor biopsy samples not only provides an assessment of prognostic and predictive factors, but may also be used for selection of biomarker-specific imaging strategies. To assess ...