Browsing by Author "Sage, Peter"

Now showing items 1-5 of 5

    • Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity 

      Paterson, Alison M.; Lovitch, Scott B.; Sage, Peter T.; Juneja, Vikram R.; Lee, Youjin; Trombley, Justin D.; Arancibia-Cárcamo, Carolina V.; Sobel, Raymond A.; Rudensky, Alexander Y.; Kuchroo, Vijay K.; Freeman, Gordon J.; Sharpe, Arlene H. (The Rockefeller University Press, 2015)
      Cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential negative regulator of T cell responses. Germline Ctla4 deficiency is lethal, making investigation of the function of CTLA-4 on mature T cells challenging. To elucidate ...

    • Mechanisms of CD4 T Cell Antigen Recognition and Effector Cell Differentiation and Function 

      Sage, Peter The (2013-03-15)
      The ability for CD4 T cells to efficiently search for and subsequently respond to microbial pathogens is essential for protective immunity, but mechanisms controlling these responses are not completely understood. In this ...

    • Negative Regulation of Humoral Immunity Due to Interplay between the SLAMF1, SLAMF5, and SLAMF6 Receptors 

      Wang, Ninghai; Halibozek, Peter J.; Yigit, Burcu; Zhao, Hui; O’Keeffe, Michael S.; Sage, Peter; Sharpe, Arlene; Terhorst, Cox (Frontiers Media S.A., 2015)
      Whereas the SLAMF-associated protein (SAP) is involved in differentiation of T follicular helper (Tfh) cells and antibody responses, the precise requirements of SLAMF receptors in humoral immune responses are incompletely ...

    • The phosphatase PTEN-mediated control of PI-3 kinase in Tregs cells maintains homeostasis and lineage stability 

      Huynh, Alexandria; DuPage, Michel; Priyadharshini, Bhavana; Sage, Peter T.; Quiros, Jason; Borges, Christopher M.; Townamchai, Natavudh; Gerriets, Valerie A.; Rathmell, Jeffrey C.; Sharpe, Arlene H.; Bluestone, Jeffrey A.; Turka, Laurence A. (2014)
      Foxp3+ regulatory T cells (Tregs) are required for immune homeostasis. One notable distinction between conventional T cells (Tconv) and Tregs is differential phosphatidylinositol 3-kinase (PI3K) activity: only Tconv ...

    • Release of cellular tension signals self-restorative ventral lamellipodia to heal barrier micro-wounds 

      Martinelli, Roberta; Kamei, Masataka; Sage, Peter T.; Massol, Ramiro; Varghese, Laya; Sciuto, Tracey; Toporsian, Mourad; Dvorak, Ann M.; Kirchhausen, Tomas; Springer, Timothy A.; Carman, Christopher V. (The Rockefeller University Press, 2013)
      Basic mechanisms by which cellular barriers sense and respond to integrity disruptions remain poorly understood. Despite its tenuous structure and constitutive exposure to disruptive strains, the vascular endothelium ...