Browsing by Author "Freedberg, Kenneth"
Now showing items 1-20 of 43
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The “ART” of Linkage: Pre-Treatment Loss to Care after HIV Diagnosis at Two PEPFAR Sites in Durban, South Africa
Losina, Elena; Bassett, Ingrid; Giddy, Janet; Chetty, Senica; Regan, Susan; Walensky, Rochelle; Ross, Douglas; Scott, Callie A.; Uhler, Lauren M.; Katz, Jeffrey; Holst, Helga; Freedberg, Kenneth (Public Library of Science (PLoS), 2010-03-04)Background Although loss to follow-up after antiretroviral therapy (ART) initiation is increasingly recognized, little is known about pre-treatment losses to care (PTLC) after an initial positive HIV test. Our objective ... -
Assessing the Performance of a Computer-Based Policy Model of HIV and AIDS
Rydzak, Chara Elaine; Cotich, Kara L.; Sax, Paul Edward; Hsu, Heather Emery Smith; Wang, Bingxia; Losina, Elena; Freedberg, Kenneth Alan; Weinstein, Milton C.; Goldie, Sue J. (2010)Background: Model-based analyses, conducted within a decision analytic framework, provide a systematic way to combine information about the natural history of disease and effectiveness of clinical management strategies ... -
Can the Heterosexual HIV Epidemic be Eliminated in South Africa Using Combination Prevention? A Modeling Analysis
Abuelezam, Nadia Natasha; McCormick, Alethea Walton; Fussell, Thomas; Afriyie, Abena N.; Wood, Robin; De Gruttola, Victor Gerard; Freedberg, Kenneth Alan; Lipsitch, Marc; Seage, George R. (Oxford University Press (OUP), 2016)Little is known about how combining efficacious HIV prevention interventions could lead to HIV elimination. We used an agent-based simulation model, the HIV Calibrated Dynamic Model (HIV-CDM), to assess the potential for ... -
The Clinical and Economic Impact of Point-of-Care CD4 Testing in Mozambique and Other Resource-Limited Settings: A Cost-Effectiveness Analysis
Hyle, Emily P.; Jani, Ilesh V.; Lehe, Jonathan; Su, Amanda E.; Wood, Robin; Quevedo, Jorge; Losina, Elena; Bassett, Ingrid V.; Pei, Pamela P.; Paltiel, A. David; Resch, Stephen; Freedberg, Kenneth A.; Peter, Trevor; Walensky, Rochelle P. (Public Library of Science, 2014)Background: Point-of-care CD4 tests at HIV diagnosis could improve linkage to care in resource-limited settings. Our objective is to evaluate the clinical and economic impact of point-of-care CD4 tests compared to ... -
Clinical Impact and Cost-Effectiveness of Expanded Voluntary HIV Testing in India
Venkatesh, Kartik K.; Becker, Jessica E.; Kumarasamy, Nagalingeswaran; Nakamura, Yoriko M.; Mayer, Kenneth H.; Losina, Elena; Swaminathan, Soumya; Flanigan, Timothy P.; Walensky, Rochelle P.; Freedberg, Kenneth A. (Public Library of Science, 2013)Background: Despite expanding access to antiretroviral therapy (ART), most of the estimated 2.3 to 2.5 million HIV-infected individuals in India remain undiagnosed. The questions of whom to test for HIV and at what frequency ... -
Cost-effectiveness of first-line antiretroviral therapy for HIV-infected African children less than 3 years of age
Ciaranello, Andrea L.; Doherty, Kathleen; Penazzato, Martina; Lindsey, Jane C.; Harrison, Linda; Kelly, Kathleen; Walensky, Rochelle P.; Essajee, Shaffiq; Losina, Elena; Muhe, Lulu; Wools-Kaloustian, Kara; Ayaya, Samuel; Weinstein, Milton C.; Palumbo, Paul; Freedberg, Kenneth A. (Lippincott Williams & Wilkins, 2015)Background: The International Maternal, Pediatric, and Adolescent Clinical Trials P1060 trial demonstrated superior outcomes for HIV-infected children less than 3 years old initiating antiretroviral therapy (ART) with ... -
Cost-Effectiveness of Genotype Testing for Primary Resistance in Brazil
Luz, Paula M.; Morris, Bethany L.; Grinsztejn, Beatriz; Freedberg, Kenneth A.; Veloso, Valdilea G.; Walensky, Rochelle P.; Losina, Elena; Nakamura, Yoriko M.; Girouard, Michael P.; Sax, Paul E.; Struchiner, Claudio J.; Paltiel, A. David (JAIDS Journal of Acquired Immune Deficiency Syndromes, 2014)Objective: HIV genotype-resistance testing can help identify more effective antiretroviral treatment (ART) regimens for patients, substantially increasing the likelihood of viral suppression and immune recovery. We sought ... -
Cost-Effectiveness of HIV Testing Referral Strategies among Tuberculosis Patients in India
Uhler, Lauren M.; Kumarasamy, Nagalingeswaran; Saxena, Anjali; Muniyandi, Malaisamy; Stoler, Adam W.; Lu, Zhigang; Flanigan, Timothy P.; Bender, Melissa A.; Swaminathan, Soumya; Mayer, Kenneth H.; Losina, Elena; Walensky, Rochelle P.; Freedberg, Kenneth Alan; Swaminathan, Soumya (Public Library of Science, 2010)Background: Indian guidelines recommend routine referral for HIV testing of all tuberculosis (TB) patients in the nine states with the highest HIV prevalence, and selective referral for testing elsewhere. We assessed the ... -
Cost-Effectiveness of Preventing Loss to Follow-up in HIV Treatment Programs: A Côte d'Ivoire Appraisal
Touré, Hapsatou; Uhler, Lauren M.; Anglaret, Xavier; Paltiel, A. David; Balestre, Eric; Messou, Eugène; Dabis, François; Losina, Elena; Walensky, Rochelle P.; Weinstein, Milton C.; Freedberg, Kenneth Alan (Public Library of Science, 2009)Background: Data from HIV treatment programs in resource-limited settings show extensive rates of loss to follow-up (LTFU) ranging from 5% to 40% within 6 mo of antiretroviral therapy (ART) initiation. Our objective was ... -
The Cost-Effectiveness of Tuberculosis Preventive Therapy for HIV-Infected Individuals in Southern India: A Trial-Based Analysis
Pho, Mai T.; Swaminathan, Soumya; Kumarasamy, Nagalingeswaran; Losina, Elena; Ponnuraja, C.; Uhler, Lauren M.; Scott, Callie A.; Mayer, Kenneth Hugh; Freedberg, Kenneth Alan; Walensky, Rochelle P. (Public Library of Science, 2012)Background: Regimens for isoniazid-based preventive therapy (IPT) for tuberculosis (TB) in HIV-infected individuals have not been widely adopted given concerns regarding efficacy, adherence and drug resistance. Further, ... -
Cost-Effectiveness of World Health Organization 2010 Guidelines for Prevention of Mother-to-Child HIV Transmission in Zimbabwe
Perez, Freddy; Engelsmann, Barbara; Mushavi, Angela; Rusibamayila, Asinath; Keatinge, Jo; Park, Ji-Eun; Maruva, Matthews; Wood, Robin; Dabis, Francois; Ciaranello, Andrea Lynne; Walensky, Rochelle P.; Cerda, Rodrigo; Freedberg, Kenneth Alan (Oxford University Press, 2012)Background. In 2010, the World Health Organization (WHO) released revised guidelines for prevention of mother-to-child human immunodeficiency virus (HIV) transmission (PMTCT). We projected clinical impacts, costs, and ... -
Cost–effectiveness of CYP2B6 genotyping to optimize efavirenz dosing in HIV clinical practice
Schackman, Bruce R; Haas, David W; Park, Sanghee S; Li, X Cynthia; Freedberg, Kenneth A (2016)Aims To assess the cost–effectiveness of CYP2B6 genotyping to guide efavirenz dosing for initial HIV therapy in the USA. Methods: We used the Cost–Effectiveness of Preventing AIDS Complications (CEPAC) microsimulation model ... -
Development, Calibration and Performance of an HIV Transmission Model Incorporating Natural History and Behavioral Patterns: Application in South Africa
McCormick, Alethea W.; Abuelezam, Nadia N.; Rhode, Erin R.; Hou, Taige; Walensky, Rochelle P.; Pei, Pamela P.; Becker, Jessica E.; DiLorenzo, Madeline A.; Losina, Elena; Freedberg, Kenneth A.; Lipsitch, Marc; Seage, George R. (Public Library of Science, 2014)Understanding HIV transmission dynamics is critical to estimating the potential population-wide impact of HIV prevention and treatment interventions. We developed an individual-based simulation model of the heterosexual ... -
Diagnostic Accuracy of a Point-of-Care Urine Test for Tuberculosis Screening Among Newly-Diagnosed HIV-Infected Adults: A Prospective, Clinic-Based Study
Drain, Paul K.; Losina, Elena; Coleman, Sharon M.; Giddy, Janet; Ross, Douglas; Katz, Jeffrey; Walensky, Rochelle; Freedberg, Kenneth; Bassett, Ingrid (Springer Science and Business Media LLC, 2014-02-26)Background A rapid diagnostic test for active tuberculosis (TB) at the clinical point-of-care could expedite case detection and accelerate TB treatment initiation. We assessed the diagnostic accuracy of a rapid urine ... -
Drug-Resistant Tuberculosis among HIV-Infected Patients Starting Antiretroviral Therapy in Durban, South Africa
Hom, Jeffrey K.; Wang, Bingxia; Chetty, Senica; Giddy, Janet; Mazibuko, Matilda; Allen, Jenny; Walensky, Rochelle P.; Losina, Elena; Freedberg, Kenneth Alan; Bassett, Ingrid Valerie (Public Library of Science, 2012)Objective: To estimate the prevalence of drug-resistant tuberculosis (TB) and describe the resistance patterns in patients commencing antiretroviral therapy (ART) in an HIV clinic in Durban, South Africa. Design ... -
Effectiveness of first-line antiretroviral therapy in the IPEC cohort, Rio de Janeiro, Brazil
Cardoso, Sandra W; Luz, Paula M; Velasque, Luciane; Torres, Thiago; Coelho, Lara; Freedberg, Kenneth A; Veloso, Valdilea G; Walensky, Rochelle P; Grinsztejn, Beatriz (BioMed Central, 2014)Background: While Brazil has had a long-standing policy of free access to antiretroviral therapy (ART) for all in need, the epidemiological impact of ART on human immunodeficiency virus (HIV) RNA suppression in this ... -
Evolution of resistance in paediatric patients with failure on antiretroviral therapy
Orrell, C; Levison, J; Ciaranello, A; Bekker, L; Kuritzkes, D; Freedberg, Kenneth Alan; Wood, R (International AIDS Society, 2012) -
Factors Associated with Self-Reported Repeat HIV Testing after a Negative Result in Durban, South Africa
Regan, Susan; Losina, Elena; Chetty, Senica; Giddy, Janet; Walensky, Rochelle P.; Ross, Douglas Sterling; Holst, Helga; Katz, Jeffrey Neil; Freedberg, Kenneth Alan; Bassett, Ingrid Valerie (Public Library of Science, 2013)Background: Routine screening for HIV infection leads to early detection and treatment. We examined patient characteristics associated with repeated screening in a high prevalence country. Methods: We analyzed data from a ... -
Food Assistance is Associated with Improved Body Mass Index, Food Security and Attendance at Clinic in an HIV Program in Central Haiti: A Prospective Observational Cohort Study
Ivers, Louise C; Chang, Yuchiao; Gregory Jerome, J; Freedberg, Kenneth Alan (BioMed Central, 2010)Background: Few data are available to guide programmatic solutions to the overlapping problems of undernutrition and HIV infection. We evaluated the impact of food assistance on patient outcomes in a comprehensive HIV ... -
High rates of unplanned interruptions from HIV care early after antiretroviral therapy initiation in Nigeria
Ahonkhai, Aimalohi A.; Banigbe, Bolanle; Adeola, Juliet; Onwuatuelo, Ifeyinwa; Bassett, Ingrid V.; Losina, Elena; Freedberg, Kenneth A.; Okonkwo, Prosper; Regan, Susan (BioMed Central, 2015)Background: Unplanned care interruption (UCI) challenges effective HIV treatment. We determined the frequency and risk factors for UCI in Nigeria. Methods: We conducted a retrospective-cohort study of adults initiating ...