Now showing items 1-20 of 41

    • Assessing the Performance of a Computer-Based Policy Model of HIV and AIDS 

      Rydzak, Chara Elaine; Cotich, Kara L.; Sax, Paul Edward; Hsu, Heather Emery Smith; Wang, Bingxia; Losina, Elena; Freedberg, Kenneth Alan; Weinstein, Milton C.; Goldie, Sue J. (2010)
      Background: Model-based analyses, conducted within a decision analytic framework, provide a systematic way to combine information about the natural history of disease and effectiveness of clinical management strategies ...
    • Can the Heterosexual HIV Epidemic be Eliminated in South Africa Using Combination Prevention? A Modeling Analysis 

      Abuelezam, Nadia Natasha; McCormick, Alethea Walton; Fussell, Thomas; Afriyie, Abena N.; Wood, Robin; De Gruttola, Victor Gerard; Freedberg, Kenneth Alan; Lipsitch, Marc; Seage, George R. (Oxford University Press (OUP), 2016)
      Little is known about how combining efficacious HIV prevention interventions could lead to HIV elimination. We used an agent-based simulation model, the HIV Calibrated Dynamic Model (HIV-CDM), to assess the potential for ...
    • The Clinical and Economic Impact of Point-of-Care CD4 Testing in Mozambique and Other Resource-Limited Settings: A Cost-Effectiveness Analysis 

      Hyle, Emily P.; Jani, Ilesh V.; Lehe, Jonathan; Su, Amanda E.; Wood, Robin; Quevedo, Jorge; Losina, Elena; Bassett, Ingrid V.; Pei, Pamela P.; Paltiel, A. David; Resch, Stephen; Freedberg, Kenneth A.; Peter, Trevor; Walensky, Rochelle P. (Public Library of Science, 2014)
      Background: Point-of-care CD4 tests at HIV diagnosis could improve linkage to care in resource-limited settings. Our objective is to evaluate the clinical and economic impact of point-of-care CD4 tests compared to ...
    • Clinical Impact and Cost-Effectiveness of Expanded Voluntary HIV Testing in India 

      Venkatesh, Kartik K.; Becker, Jessica E.; Kumarasamy, Nagalingeswaran; Nakamura, Yoriko M.; Mayer, Kenneth H.; Losina, Elena; Swaminathan, Soumya; Flanigan, Timothy P.; Walensky, Rochelle P.; Freedberg, Kenneth A. (Public Library of Science, 2013)
      Background: Despite expanding access to antiretroviral therapy (ART), most of the estimated 2.3 to 2.5 million HIV-infected individuals in India remain undiagnosed. The questions of whom to test for HIV and at what frequency ...
    • Cost-effectiveness of first-line antiretroviral therapy for HIV-infected African children less than 3 years of age 

      Ciaranello, Andrea L.; Doherty, Kathleen; Penazzato, Martina; Lindsey, Jane C.; Harrison, Linda; Kelly, Kathleen; Walensky, Rochelle P.; Essajee, Shaffiq; Losina, Elena; Muhe, Lulu; Wools-Kaloustian, Kara; Ayaya, Samuel; Weinstein, Milton C.; Palumbo, Paul; Freedberg, Kenneth A. (Lippincott Williams & Wilkins, 2015)
      Background: The International Maternal, Pediatric, and Adolescent Clinical Trials P1060 trial demonstrated superior outcomes for HIV-infected children less than 3 years old initiating antiretroviral therapy (ART) with ...
    • Cost-Effectiveness of Genotype Testing for Primary Resistance in Brazil 

      Luz, Paula M.; Morris, Bethany L.; Grinsztejn, Beatriz; Freedberg, Kenneth A.; Veloso, Valdilea G.; Walensky, Rochelle P.; Losina, Elena; Nakamura, Yoriko M.; Girouard, Michael P.; Sax, Paul E.; Struchiner, Claudio J.; Paltiel, A. David (JAIDS Journal of Acquired Immune Deficiency Syndromes, 2014)
      Objective: HIV genotype-resistance testing can help identify more effective antiretroviral treatment (ART) regimens for patients, substantially increasing the likelihood of viral suppression and immune recovery. We sought ...
    • Cost-Effectiveness of HIV Testing Referral Strategies among Tuberculosis Patients in India 

      Uhler, Lauren M.; Kumarasamy, Nagalingeswaran; Saxena, Anjali; Muniyandi, Malaisamy; Stoler, Adam W.; Lu, Zhigang; Flanigan, Timothy P.; Bender, Melissa A.; Swaminathan, Soumya; Mayer, Kenneth H.; Losina, Elena; Walensky, Rochelle P.; Freedberg, Kenneth Alan; Swaminathan, Soumya (Public Library of Science, 2010)
      Background: Indian guidelines recommend routine referral for HIV testing of all tuberculosis (TB) patients in the nine states with the highest HIV prevalence, and selective referral for testing elsewhere. We assessed the ...
    • Cost-Effectiveness of Preventing Loss to Follow-up in HIV Treatment Programs: A Côte d'Ivoire Appraisal 

      Touré, Hapsatou; Uhler, Lauren M.; Anglaret, Xavier; Paltiel, A. David; Balestre, Eric; Messou, Eugène; Dabis, François; Losina, Elena; Walensky, Rochelle P.; Weinstein, Milton C.; Freedberg, Kenneth Alan (Public Library of Science, 2009)
      Background: Data from HIV treatment programs in resource-limited settings show extensive rates of loss to follow-up (LTFU) ranging from 5% to 40% within 6 mo of antiretroviral therapy (ART) initiation. Our objective was ...
    • The Cost-Effectiveness of Tuberculosis Preventive Therapy for HIV-Infected Individuals in Southern India: A Trial-Based Analysis 

      Pho, Mai T.; Swaminathan, Soumya; Kumarasamy, Nagalingeswaran; Losina, Elena; Ponnuraja, C.; Uhler, Lauren M.; Scott, Callie A.; Mayer, Kenneth Hugh; Freedberg, Kenneth Alan; Walensky, Rochelle P. (Public Library of Science, 2012)
      Background: Regimens for isoniazid-based preventive therapy (IPT) for tuberculosis (TB) in HIV-infected individuals have not been widely adopted given concerns regarding efficacy, adherence and drug resistance. Further, ...
    • Cost-Effectiveness of World Health Organization 2010 Guidelines for Prevention of Mother-to-Child HIV Transmission in Zimbabwe 

      Perez, Freddy; Engelsmann, Barbara; Mushavi, Angela; Rusibamayila, Asinath; Keatinge, Jo; Park, Ji-Eun; Maruva, Matthews; Wood, Robin; Dabis, Francois; Ciaranello, Andrea Lynne; Walensky, Rochelle P.; Cerda, Rodrigo; Freedberg, Kenneth Alan (Oxford University Press, 2012)
      Background. In 2010, the World Health Organization (WHO) released revised guidelines for prevention of mother-to-child human immunodeficiency virus (HIV) transmission (PMTCT). We projected clinical impacts, costs, and ...
    • Cost–effectiveness of CYP2B6 genotyping to optimize efavirenz dosing in HIV clinical practice 

      Schackman, Bruce R; Haas, David W; Park, Sanghee S; Li, X Cynthia; Freedberg, Kenneth A (2016)
      Aims To assess the cost–effectiveness of CYP2B6 genotyping to guide efavirenz dosing for initial HIV therapy in the USA. Methods: We used the Cost–Effectiveness of Preventing AIDS Complications (CEPAC) microsimulation model ...
    • Development, Calibration and Performance of an HIV Transmission Model Incorporating Natural History and Behavioral Patterns: Application in South Africa 

      McCormick, Alethea W.; Abuelezam, Nadia N.; Rhode, Erin R.; Hou, Taige; Walensky, Rochelle P.; Pei, Pamela P.; Becker, Jessica E.; DiLorenzo, Madeline A.; Losina, Elena; Freedberg, Kenneth A.; Lipsitch, Marc; Seage, George R. (Public Library of Science, 2014)
      Understanding HIV transmission dynamics is critical to estimating the potential population-wide impact of HIV prevention and treatment interventions. We developed an individual-based simulation model of the heterosexual ...
    • Drug-Resistant Tuberculosis among HIV-Infected Patients Starting Antiretroviral Therapy in Durban, South Africa 

      Hom, Jeffrey K.; Wang, Bingxia; Chetty, Senica; Giddy, Janet; Mazibuko, Matilda; Allen, Jenny; Walensky, Rochelle P.; Losina, Elena; Freedberg, Kenneth Alan; Bassett, Ingrid Valerie (Public Library of Science, 2012)
      Objective: To estimate the prevalence of drug-resistant tuberculosis (TB) and describe the resistance patterns in patients commencing antiretroviral therapy (ART) in an HIV clinic in Durban, South Africa. Design ...
    • Effectiveness of first-line antiretroviral therapy in the IPEC cohort, Rio de Janeiro, Brazil 

      Cardoso, Sandra W; Luz, Paula M; Velasque, Luciane; Torres, Thiago; Coelho, Lara; Freedberg, Kenneth A; Veloso, Valdilea G; Walensky, Rochelle P; Grinsztejn, Beatriz (BioMed Central, 2014)
      Background: While Brazil has had a long-standing policy of free access to antiretroviral therapy (ART) for all in need, the epidemiological impact of ART on human immunodeficiency virus (HIV) RNA suppression in this ...
    • Evolution of resistance in paediatric patients with failure on antiretroviral therapy 

      Orrell, C; Levison, J; Ciaranello, A; Bekker, L; Kuritzkes, D; Freedberg, Kenneth Alan; Wood, R (International AIDS Society, 2012)
    • Factors Associated with Self-Reported Repeat HIV Testing after a Negative Result in Durban, South Africa 

      Regan, Susan; Losina, Elena; Chetty, Senica; Giddy, Janet; Walensky, Rochelle P.; Ross, Douglas Sterling; Holst, Helga; Katz, Jeffrey Neil; Freedberg, Kenneth Alan; Bassett, Ingrid Valerie (Public Library of Science, 2013)
      Background: Routine screening for HIV infection leads to early detection and treatment. We examined patient characteristics associated with repeated screening in a high prevalence country. Methods: We analyzed data from a ...
    • Food Assistance is Associated with Improved Body Mass Index, Food Security and Attendance at Clinic in an HIV Program in Central Haiti: A Prospective Observational Cohort Study 

      Ivers, Louise C; Chang, Yuchiao; Gregory Jerome, J; Freedberg, Kenneth Alan (BioMed Central, 2010)
      Background: Few data are available to guide programmatic solutions to the overlapping problems of undernutrition and HIV infection. We evaluated the impact of food assistance on patient outcomes in a comprehensive HIV ...
    • High rates of unplanned interruptions from HIV care early after antiretroviral therapy initiation in Nigeria 

      Ahonkhai, Aimalohi A.; Banigbe, Bolanle; Adeola, Juliet; Onwuatuelo, Ifeyinwa; Bassett, Ingrid V.; Losina, Elena; Freedberg, Kenneth A.; Okonkwo, Prosper; Regan, Susan (BioMed Central, 2015)
      Background: Unplanned care interruption (UCI) challenges effective HIV treatment. We determined the frequency and risk factors for UCI in Nigeria. Methods: We conducted a retrospective-cohort study of adults initiating ...
    • HIV Cure Strategies: How Good Must They Be to Improve on Current Antiretroviral Therapy? 

      Sax, Paul E.; Sypek, Alexis; Berkowitz, Bethany K.; Morris, Bethany L.; Losina, Elena; Paltiel, A. David; Kelly, Kathleen A.; Seage, George R.; Walensky, Rochelle P.; Weinstein, Milton C.; Eron, Joseph; Freedberg, Kenneth A. (Public Library of Science, 2014)
      Background: We examined efficacy, toxicity, relapse, cost, and quality-of-life thresholds of hypothetical HIV cure interventions that would make them cost-effective compared to life-long antiretroviral therapy (ART). ...
    • Improving HIV Outcomes in Resource-Limited Countries: The Importance of Quality Indicators 

      Ahonkhai, Aimalohi A; Bassett, Ingrid Valerie; Ferris, Timothy Gregg; Freedberg, Kenneth Alan (BioMed Central, 2012)
      Background: Resource-limited countries increasingly depend on quality indicators to improve outcomes within HIV treatment programs, but indicators of program performance suitable for use at the local program level remain ...