Browsing by Author "Kuchroo, Vijay"

Now showing items 21-27 of 27

    • T cell–derived interleukin (IL)-21 promotes brain injury following stroke in mice 

      Clarkson, Benjamin D.S.; Ling, Changying; Shi, Yejie; Harris, Melissa G.; Rayasam, Aditya; Sun, Dandan; Salamat, M. Shahriar; Kuchroo, Vijay; Lambris, John D.; Sandor, Matyas; Fabry, Zsuzsanna (The Rockefeller University Press, 2014)
      T lymphocytes are key contributors to the acute phase of cerebral ischemia reperfusion injury, but the relevant T cell–derived mediators of tissue injury remain unknown. Using a mouse model of transient focal brain ischemia, ...

    • Targeting PGLYRP1 promotes antitumor immunity while inhibiting autoimmune neuroinflammation 

      Schnell, Alexandra; Huang, Linglin; Regan, Brianna; Vonficht, Dominik; Bollhagen, Alina; Wang, Mona; Hou, Yu; Bod, Lloyd; Chihara, Norio; Madi, Asaf; Anderson, Ana; Kuchroo, Vijay (Springer Science and Business Media LLC, 2023-10-12)
      Co-inhibitory and checkpoint molecules suppress T-cell function in the tumor microenvironment, thereby rendering T cells dysfunctional. While immune checkpoint blockade (ICB) has emerged as a successful treatment option ...

    • Targeting Tim-3 and PD-1 Pathways to Reverse T Cell Exhaustion and Restore Anti-Tumor Immunity 

      Sakuishi, Kaori; Apetoh, Lionel; Sullivan, Jenna M.; Blazar, Bruce R.; Kuchroo, Vijay Kumar; Anderson, Ana Carrizosa (The Rockefeller University Press, 2010)
      The immune response plays an important role in staving off cancer; however, mechanisms of immunosuppression hinder productive anti-tumor immunity. T cell dysfunction or exhaustion in tumor-bearing hosts is one such mechanism. ...

    • TGF-β Signaling Initiated in Dendritic Cells Instructs Suppressive Effects on Th17 Differentiation at the Site of Neuroinflammation 

      Speck, Suzanne; Lim, James; Shelake, Sagar; Matka, Marsel; Stoddard, Jonathan; Farr, Alexander; Kuchroo, Vijay; Laouar, Yasmina (Public Library of Science, 2014)
      While the role of Transforming Growth Factor β (TGF-β) as an intrinsic pathway has been well established in driving de novo differentiation of Th17 cells, no study has directly assessed the capacity of TGF-β signaling ...

    • TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection 

      Jayaraman, Pushpa; Jacques, Miye K.; Zhu, Chen; Steblenko, Katherine M.; Stowell, Britni L.; Madi, Asaf; Anderson, Ana C.; Kuchroo, Vijay K.; Behar, Samuel M. (Public Library of Science, 2016)
      While T cell immunity initially limits Mycobacterium tuberculosis infection, why T cell immunity fails to sterilize the infection and allows recrudescence is not clear. One hypothesis is that T cell exhaustion impairs ...

    • TIM3+FOXP3+ regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer 

      Sakuishi, Kaori; Ngiow, Shin Foong; Sullivan, Jenna M.; Teng, Michele W. L.; Kuchroo, Vijay K.; Smyth, Mark J.; Anderson, Ana C. (Landes Bioscience, 2013)
      T-cell immunoglobulin mucin 3 (TIM3) is an inhibitory molecule that has emerged as a key regulator of dysfunctional or exhausted CD8+ T cells arising in chronic diseases such as cancer. In addition to exhausted CD8+ T ...

    • Upregulation of Tim-3 and PD-1 Expression is Associated with Tumor Antigen-Specific CD8\(^+\) T Cell Dysfunction in Melanoma Patients 

      Fourcade, Julien; Sun, Zhaojun; Benallaoua, Mourad; Guillaume, Philippe; Luescher, Immanuel F.; Sander, Cindy; Kirkwood, John M.; Kuchroo, Vijay Kumar; Zarour, Hassane M. (The Rockefeller University Press, 2010)
      The paradoxical coexistence of spontaneous tumor antigen–specific immune responses with progressive disease in cancer patients furthers the need to dissect the molecular pathways involved in tumor-induced T cell dysfunction. ...