Browsing by Keyword "Internal Medicine"

Now showing items 1-20 of 26

    • 87 Rare Variants Associated With Blood Pressure in Meta-Analysis of ∼1.32 Million Individuals 

      Feofanova, Elena; Franks, Paul (Ovid Technologies (Wolters Kluwer Health), 2021-04)
      Genetic studies of blood pressure (BP) to date have mainly analysed common variants (minor allele frequency, MAF>0.05). In a meta-analysis of up to >1.3 million participants, we discovered 106 new BP-associated genomic ...

    • Clinical Laboratory Test Findings in Patients with Chronic Fatigue Syndrome 

      Bates, David; Buchwald, Dedra; Lee, Joshua; Kith, Phalla; Doolittle, Teresa; Rutherford, Cynthia; Churchill, W.; Schur, Peter; Wener, Mark; Wybenga, Donald; Winkelman, James; Komaroff, Anthony (American Medical Association (AMA), 1995-01-09)
      Background: Results of readily available clinical laboratory tests in patients with chronic fatigue syndrome were compared with results in healthy control subjects. Methods: Cases consisted of all 579 patients who met ...

    • Continuous Positive Airway Pressure 

      Babar, Sardar I.; Quan, Stuart (American Medical Association (AMA), 2003-03-10)

    • Does the Computerized Display of Charges Affect Inpatient Ancillary Test Utilization? 

      Bates, David; Kuperman, Gilad J.; Jha, Ashish; Teich, Jonathan; Orav, Endel; Ma'luf, Nell; Onderdonk, Andrew; Pugatch, Robert; Wybenga, Donald; Winkelman, James; Brennan, Troyen; Komaroff, Anthony; Tanasijevic, Milenko (American Medical Association (AMA), 1997-11-24)
      Background: The computerized display of charges for ancillary tests in outpatients has been found to affect physician-ordering behavior, but this issue has not been studied in inpatients. Objective: To assess whether ...

    • Effects of Computerized Physician Order Entry on Prescribing Practices 

      Merchia, Pankaj R.; Schmiz, Jennifer L.; Spurr, Cynthia D.; Teich, Jonathan; Kuperman, Gilad; Bates, David W (American Medical Association (AMA), 2000-10-09)
      Background: Computerized order entry systems have the potential to prevent errors, to improve quality of care, and to reduce costs by providing feedback and suggestions to the physician as each order is entered. This study ...

    • An enolase inhibitor for the targeted treatment of ENO1-deleted cancers 

      Lin, Yu-Hsi; Satani, Nikunj; Hammoudi, Naima; Yan, Victoria C.; Barekatain, Yasaman; Khadka, Sunada; Ackroyd, Jeffrey J.; Georgiou, Dimitra K.; Pham, Cong-Dat; Arthur, Kenisha; Maxwell, David; Peng, Zhenghong; Leonard, Paul G.; Czako, Barbara; Pisaneschi, Federica; Mandal, Pijus; Sun, Yuting; Zielinski, Rafal; Pando, Susana Castro; Wang, Xiaobo; Tran, Theresa; Xu, Quanyu; Wu, Qi; Jiang, Yongying; Kang, Zhijun; Asara, John; Priebe, Waldemar; Bornmann, William; Marszalek, Joseph R.; DePinho, Ronald A.; Muller, Florian L. (Springer Science and Business Media LLC, 2020-11-23)
      Inhibiting glycolysis remains an aspirational approach for the treatment of cancer. We previously identified a subset of cancers harboring homozygous deletion of the glycolytic enzyme Enolase (ENO1) with exceptional ...

    • Evaluating the Appropriateness of Digoxin Level Monitoring 

      Cañas, Fina; Ma'luf, Nell; Bates, David; Tanasijevic, Milenko (American Medical Association (AMA), 1999-02-22)
      Background Digoxin level determinations can be useful clinically in patients receiving digoxin therapy but are sometimes misused. Methods Explicit appropriateness criteria were adapted from previously published criteria ...

    • Evaluation and Treatment of Pharyngitis in Primary Care Practice 

      Linder, Jeffrey; Chan, Joseph C.; Bates, David (American Medical Association (AMA), 2006-07-10)
      Background The guidelines from the American College of Physicians and the Infectious Diseases Society of America differ with respect to the use of clinical criteria and microbiologic testing to identify adults with ...

    • Every Body Counts: Measuring Mortality From the COVID-19 Pandemic 

      Kiang, Mathew; Irizarry, Rafael; Buckee, Caroline; Balsari, Satchit (American College of Physicians, 2020-09-11)
      As of mid-August 2020, more than 170 000 U.S. residents have died of coronavirus disease 2019 (COVID-19); however, the true number of deaths resulting from COVID-19, both directly and indirectly, is likely to be much higher. ...

    • Genome-Scale in Vivo CRISPR Screen Identifies RNLS as a Target for Beta Cell Protection in Type 1 Diabetes 

      Cai, Erica P.; Ishikawa, Yuki; Zhang, Wei; de Carvalho Leite, Nayara; Li, Jian; Hou, Shurong; Kiaf, Badr; Hollister-Lock, Jennifer; Yilmaz, Nese Kurt; Schiffer, Celia A.; Melton, Douglas; Kissler, Stephan; Yi, Peng (Springer Science and Business Media LLC, 2020-07-27)
      Type 1 diabetes (T1D) is caused by the autoimmune destruction of pancreatic beta cells. Pluripotent stem cells can now be differentiated into beta cells, raising the prospect of a cell replacement therapy for T1D. However, ...

    • Global and Regional Effects of Type 2 Diabetes on Brain Tissue Volumes and Cerebral Vasoreactivity 

      Last, David; Alsop, David; Abduljalil, Amir; Marquis, Robert P.; de Bazelaire, Cedric; Hu, Kun; Cavallerano, Jerry; Novak, Vera (American Diabetes Association, 2007-02-08)
      OBJECTIVE—The aim of this study was to evaluate the regional effects of type 2 diabetes and associated conditions on cerebral tissue volumes and cerebral blood flow (CBF) regulation. RESEARCH DESIGN AND METHODS—CBF was ...

    • High-Deductible Insurance and Delay in Care for the Macrovascular Complications of Diabetes 

      Wharam, J. Frank; Lu, Christine Y.; Zhang, Fang; Callahan, Matthew; Xu, Xin; Wallace, Jamie; Soumerai, Stephen; Ross-Degnan, Dennis; Newhouse, Joseph (American College of Physicians, 2018-11-20)
      Background: Little is known about the long-term effects of high-deductible insurance on care for chronic medical conditions. Objective: To determine whether a transition from low-deductible to high-deductible insurance ...

    • Hypertension and Cerebral Vasoreactivity 

      Hajjar, Ihab; Zhao, Peng; Alsop, David; Novak, Vera (Ovid Technologies (Wolters Kluwer Health), 2010-11)
      Hypertension is associated with microvascular and macrovascular brain injury but its direct influence on the cerebral circulation is not fully clear. Our objective was to investigate the association of hypertension with ...

    • Impact of an Automated Test Results Management System on Patients' Satisfaction About Test Result Communication 

      Matheny, Michael; Gandhi, Tejal; Orav, Endel; Ladak-Merchant, Zahra; Bates, David W.; Kuperman, Gilad J.; Poon, Eric G. (American Medical Association (AMA), 2007-11-12)
      Background: Few reliable and efficient systems sup- port the communication of test results to outpatients, and this may lead to patient dissatisfaction with test result communication. The objective of this study was to ...

    • Increased β-Cell Proliferation Before Immune Cell Invasion Prevents Progression of Type 1 Diabetes 

      Dirice, Ercument; Kahraman, Sevim; De Jesus, Dario F.; El Ouaamari, Abdelfattah; Basile, Giorgio; Baker, Rocky L.; Yigit, Burcu; Piehowski, Paul D.; Kim, Mi-Jeong; Dwyer, Alexander J.; Ng, Raymond; Schuster, Cornelia; Vethe, Heidrun; Martinov, Tijana; Ishikawa, Yuki; Teo, Adrian Kee Keong; Smith, Richard D.; Hu, Jiang; Haskins, Kathryn; Serwold, Thomas; Qian, Wei-Jun; Fife, Brian T.; Kissler, Stephan; Kulkarni, Rohit (Springer Science and Business Media LLC, 2019-05-06)
      Type 1 diabetes (T1D) is characterized by pancreatic islet infiltration by autoreactive immune cells and a near-total loss of β-cells1. Restoration of insulin-producing β-cells coupled with immunomodulation to suppress the ...

    • The Natural History of Insomnia and Its Relationship to Respiratory Symptoms 

      Dodge, Russell; Cline, Martha; Quan, Stuart (American Medical Association (AMA), 1995-09-11)
      Background: Although insomnia is a frequent complaint among patients, epidemiologic study has been limited. Researchers have reported a wide range in the prevalence of this complaint in a variety of selected populations. ...

    • Patient-Reported Medication Symptoms in Primary Care 

      Weingart, Saul N.; Gandhi, Tejal; Seger, Andrew; Seger, Diane L.; Borus, Joshua; Burdick, Elizabeth; Leape, Lucian; Bates, David (American Medical Association (AMA), 2005-01-24)
      Background Little is known about the prevalence and character of medication-related symptoms in primary care and their relationship to adverse drug events (ADEs) or about factors that affect patient-physician communication ...

    • Preoperative Hyponatremia and Perioperative Complications 

      Leung, Alexander A.; McAlister, Finlay A.; Rogers, Selwyn O.; Pazo, Valeria; Bates, David W.; Wright, Adam (American Medical Association (AMA), 2012-10-22)
      Background Although hyponatremia has been linked to increased morbidity and mortality in a variety of medical conditions, its association with perioperative outcomes remains uncertain. Methods To determine whether ...

    • Probiotic Safety—Reasonable Certainty of No Harm—Reply 

      Cohen, Pieter (American Medical Association (AMA), 2019-02-01)

    • Rapid Diagnosis of Pulmonary Coccidioidomycosis: Cytologic v Potassium Hydroxide Preparations 

      Warlick, Michael A.; Quan, Stuart; Sobonya, Richard E. (American Medical Association (AMA), 1983-04)
      In 26 patients with culture-proved pulmonary coccidioidomycosis, cytologic preparations of respiratory secretions were significantly more sensitive (38.5%) than potassium hydroxide (KOH) preparations (15.4%) in identifying ...