Publication: Immunovirotherapy for the treatment of glioblastoma
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Date
2014
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Landes Bioscience
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Citation
Cheema, Tooba A, Peter E Fecci, Jianfang Ning, and Samuel D Rabkin. 2014. “Immunovirotherapy for the treatment of glioblastoma.” Oncoimmunology 3 (1): e27218. doi:10.4161/onci.27218. http://dx.doi.org/10.4161/onci.27218.
Abstract
We have recently described a new murine model of glioblastoma, generated by the implantation of syngeneic glioblastoma stem cells into immunocompetent mice, that recapitulates the salient histopathological and immunological features of the human disease. We employed this model to demonstrate the multifaceted activity of an oncolytic herpes simplex virus genetically modified to express interleukin-12, G47∆-IL12.
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Keywords
cancer stem cells, glioma, herpes simplex virus, interleukin-12, oncolytic virus, Treg
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