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3D Bioprinting of Vascularized, Heterogeneous Cell-Laden Tissue Constructs

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2014

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Wiley-Blackwell
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Kolesky, David B., Ryan L. Truby, A. Sydney Gladman, Travis A. Busbee, Kimberly A. Homan, and Jennifer A. Lewis. 2014. “3D Bioprinting of Vascularized, Heterogeneous Cell-Laden Tissue Constructs.” In Advanced Materials 26, no. 19: 3124–3130. doi:10.1002/adma.201305506.

Abstract

A new bioprinting method is reported for fabricating 3D tissue constructs replete with vasculature, multiple types of cells, and extracellular matrix. These intricate, heterogeneous structures are created by precisely co-printing multiple materials, known as bioinks, in three dimensions. These 3D micro-engineered environments open new ­avenues for drug screening and fundamental studies of wound healing, angiogenesis, and stem-cell niches.

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